Liver mitochondrial respiratory functions decline with age

Tzu Chen Yen; Yu Sheng Chen; Kwang Laing King; Shin Hwa Yeh; Yau Huei Wei

doi:10.1016/0006-291X(89)92701-0

Liver mitochondrial respiratory functions decline with age

Tzu Chen Yen^*
, Yu Sheng Chen
, Kwang Laing King
, Shin Hwa Yeh
, Yau Huei Wei

^*Corresponding author for this work

National Yang Ming Chiao Tung University
Veterans General Hospital-Taipei

Research output: Contribution to journal › Journal Article › peer-review

300 Scopus citations

Abstract

Human liver mitochondrial respiration rates in Chinese populations of various ages were assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76 years old. We found a significant negative correlation between age and respiration rate with all substrates tested. Moreover, the respiratory control and ADP/O ratios decreased with the increase of age. These findings suggest that a substantial fall in mitochondrial oxidative capacity in ageing liver may be an important contributor to the ageing process.

Original language	English
Pages (from-to)	994-1003
Number of pages	10
Journal	Biochemical and Biophysical Research Communications
Volume	165
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(89)92701-0
State	Published - 30 12 1989
Externally published	Yes

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title = "Liver mitochondrial respiratory functions decline with age",

abstract = "Human liver mitochondrial respiration rates in Chinese populations of various ages were assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76 years old. We found a significant negative correlation between age and respiration rate with all substrates tested. Moreover, the respiratory control and ADP/O ratios decreased with the increase of age. These findings suggest that a substantial fall in mitochondrial oxidative capacity in ageing liver may be an important contributor to the ageing process.",

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AU - Yen, Tzu Chen

AU - Chen, Yu Sheng

AU - King, Kwang Laing

AU - Yeh, Shin Hwa

AU - Wei, Yau Huei

PY - 1989/12/30

Y1 - 1989/12/30

N2 - Human liver mitochondrial respiration rates in Chinese populations of various ages were assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76 years old. We found a significant negative correlation between age and respiration rate with all substrates tested. Moreover, the respiratory control and ADP/O ratios decreased with the increase of age. These findings suggest that a substantial fall in mitochondrial oxidative capacity in ageing liver may be an important contributor to the ageing process.

AB - Human liver mitochondrial respiration rates in Chinese populations of various ages were assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76 years old. We found a significant negative correlation between age and respiration rate with all substrates tested. Moreover, the respiratory control and ADP/O ratios decreased with the increase of age. These findings suggest that a substantial fall in mitochondrial oxidative capacity in ageing liver may be an important contributor to the ageing process.

UR - https://www.scopus.com/pages/publications/0024980878

U2 - 10.1016/0006-291X(89)92701-0

DO - 10.1016/0006-291X(89)92701-0

M3 - 文章

C2 - 2610701

AN - SCOPUS:0024980878

SN - 0006-291X

VL - 165

SP - 994

EP - 1003

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Liver mitochondrial respiratory functions decline with age

Abstract

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