Localization and function of tissue macrophages.

S. Gordon; P. R. Crocker; L. Morris; S. H. Lee; V. H. Perry; D. A. Hume

Localization and function of tissue macrophages.

S. Gordon^*
, P. R. Crocker
, L. Morris
, S. H. Lee
, V. H. Perry
, D. A. Hume

^*Corresponding author for this work

Unknown

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

The rat monoclonal antibody F4/80 defines a plasma membrane glycoprotein of about 160 kilodaltons that is expressed by mature mouse macrophages. The antigen has been used to define macrophage distribution within the mouse (normal adult, embryo, infection models) by cytochemistry and quantitative immunochemical analysis. Macrophages migrate into fetal and adult haemopoietic and other tissues in an ordered sequence. The surface properties of 'fixed' macrophages isolated from various organs (bone marrow, liver, spleen) are distinct from those of circulating monocytes or free cells (peritoneal and pleural cavities, alveolar) and may play a role in local adhesion and trophic interactions with other cells.

Original language	English
Pages (from-to)	54-67
Number of pages	14
Journal	Ciba Foundation symposium
Volume	118
State	Published - 1986
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "Localization and function of tissue macrophages.",

abstract = "The rat monoclonal antibody F4/80 defines a plasma membrane glycoprotein of about 160 kilodaltons that is expressed by mature mouse macrophages. The antigen has been used to define macrophage distribution within the mouse (normal adult, embryo, infection models) by cytochemistry and quantitative immunochemical analysis. Macrophages migrate into fetal and adult haemopoietic and other tissues in an ordered sequence. The surface properties of 'fixed' macrophages isolated from various organs (bone marrow, liver, spleen) are distinct from those of circulating monocytes or free cells (peritoneal and pleural cavities, alveolar) and may play a role in local adhesion and trophic interactions with other cells.",

author = "S. Gordon and Crocker, \{P. R.\} and L. Morris and Lee, \{S. H.\} and Perry, \{V. H.\} and Hume, \{D. A.\}",

year = "1986",

language = "英语",

volume = "118",

pages = "54--67",

journal = "Ciba Foundation symposium",

issn = "0300-5208",

publisher = "Novartis Foundation",

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TY - JOUR

T1 - Localization and function of tissue macrophages.

AU - Gordon, S.

AU - Crocker, P. R.

AU - Morris, L.

AU - Lee, S. H.

AU - Perry, V. H.

AU - Hume, D. A.

PY - 1986

Y1 - 1986

N2 - The rat monoclonal antibody F4/80 defines a plasma membrane glycoprotein of about 160 kilodaltons that is expressed by mature mouse macrophages. The antigen has been used to define macrophage distribution within the mouse (normal adult, embryo, infection models) by cytochemistry and quantitative immunochemical analysis. Macrophages migrate into fetal and adult haemopoietic and other tissues in an ordered sequence. The surface properties of 'fixed' macrophages isolated from various organs (bone marrow, liver, spleen) are distinct from those of circulating monocytes or free cells (peritoneal and pleural cavities, alveolar) and may play a role in local adhesion and trophic interactions with other cells.

AB - The rat monoclonal antibody F4/80 defines a plasma membrane glycoprotein of about 160 kilodaltons that is expressed by mature mouse macrophages. The antigen has been used to define macrophage distribution within the mouse (normal adult, embryo, infection models) by cytochemistry and quantitative immunochemical analysis. Macrophages migrate into fetal and adult haemopoietic and other tissues in an ordered sequence. The surface properties of 'fixed' macrophages isolated from various organs (bone marrow, liver, spleen) are distinct from those of circulating monocytes or free cells (peritoneal and pleural cavities, alveolar) and may play a role in local adhesion and trophic interactions with other cells.

UR - https://www.scopus.com/pages/publications/0022438725

M3 - 文献综述

C2 - 3525039

AN - SCOPUS:0022438725

SN - 0300-5208

VL - 118

SP - 54

EP - 67

JO - Ciba Foundation symposium

JF - Ciba Foundation symposium

ER -

Localization and function of tissue macrophages.

Abstract

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