Localized cutaneous polyvinylpyrrolidone storage disease mimicking cheilitis granulomatosa

Ching Chi Chi, Shu Hui Wang*, Tseng-Tong Kuo

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

17 Scopus citations


Abstract: Polyvinylpyrrolidone (PVP), a polymer of the monomer N-vinylpyrrolidone with various molecular weights, was originally developed as a plasma expander. Currently, it is widely used in hair sprays, skin care products, fruit juices, and as a retarding agent in drugs such as procaine and hormones. PVP polymers with a molecular weight greater than 20,000 cannot be excreted by the kidneys and therefore are phagocytosed and permanently stored in the reticular endothelial system, leading to the so-called PVP storage disease. We report a case of localized cutaneous PVP storage disease presenting with persistent upper lip swelling and mimicking cheilitis granulomatosa, which has never been reported before.

Original languageEnglish
Pages (from-to)454-457
Number of pages4
JournalJournal of Cutaneous Pathology
Issue number6
StatePublished - 06 2006


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