Long-term effects of surgical treatment on baroreflex function in patients with obstructive sleep apnea: an 18-month follow-up

Chih Cheng Huang; Hsin Ching Lin; Yun Ru Lai; Nai Wen Tsai; Wei Che Lin; Hung Chen Wang; Chia Te Kung; Ben Chung Cheng; Yu Jih Su; Chih Min Su; Sheng Yuan Hsiao; Cheng Hsien Lu

doi:10.1016/j.sleep.2019.03.017

Long-term effects of surgical treatment on baroreflex function in patients with obstructive sleep apnea: an 18-month follow-up

Chih Cheng Huang
, Hsin Ching Lin
, Yun Ru Lai
, Nai Wen Tsai
, Wei Che Lin
, Hung Chen Wang
, Chia Te Kung
, Ben Chung Cheng
, Yu Jih Su
, Chih Min Su
, Sheng Yuan Hsiao
, Cheng Hsien Lu^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

Objective: Depressed baroreflex sensitivity (BRS) is reported in obstructive sleep apnea (OSA). Improvement of BRS short-term after surgical treatment is also reported. We tested the hypothesis that surgical treatment not only improves clinical outcomes, but also improves BRS after 18 months. Methods: Cardiovascular autonomic tests, polysomnography (PSG), and biochemical testing were prospectively evaluated in 54 OSA patients at three time points (preoperatively, 6 months and 18 months postoperatively) and compared with 20, age- and body mass index (BMI)-matched, healthy controls. Results: The BRS increased after surgical treatment at 18-month follow-up, with results similar to the healthy control. Additionally, average O₂, mO₂ <90% (% per night), and lowest O₂ showed an increase after surgical treatment at the 18-month follow-up. Conclusions: Besides improvement in clinical outcomes, depressed BRS in OSA patients is reversible and these patients have the potential for total recovery of baroreflex function after 18 months of treatment.

Original language	English
Pages (from-to)	152-158
Number of pages	7
Journal	Sleep Medicine
Volume	60
DOIs	https://doi.org/10.1016/j.sleep.2019.03.017
State	Published - 08 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier B.V.

Keywords

Baroreflex sensitivity
Long-term effects
Obstructive sleep apnea
Surgical outcome

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10.1016/j.sleep.2019.03.017

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@article{44c21fd2cac840ae85384a8b654f3605,

title = "Long-term effects of surgical treatment on baroreflex function in patients with obstructive sleep apnea: an 18-month follow-up",

abstract = "Objective: Depressed baroreflex sensitivity (BRS) is reported in obstructive sleep apnea (OSA). Improvement of BRS short-term after surgical treatment is also reported. We tested the hypothesis that surgical treatment not only improves clinical outcomes, but also improves BRS after 18 months. Methods: Cardiovascular autonomic tests, polysomnography (PSG), and biochemical testing were prospectively evaluated in 54 OSA patients at three time points (preoperatively, 6 months and 18 months postoperatively) and compared with 20, age- and body mass index (BMI)-matched, healthy controls. Results: The BRS increased after surgical treatment at 18-month follow-up, with results similar to the healthy control. Additionally, average O2, mO2 <90\% (\% per night), and lowest O2 showed an increase after surgical treatment at the 18-month follow-up. Conclusions: Besides improvement in clinical outcomes, depressed BRS in OSA patients is reversible and these patients have the potential for total recovery of baroreflex function after 18 months of treatment.",

keywords = "Baroreflex sensitivity, Long-term effects, Obstructive sleep apnea, Surgical outcome",

author = "Huang, \{Chih Cheng\} and Lin, \{Hsin Ching\} and Lai, \{Yun Ru\} and Tsai, \{Nai Wen\} and Lin, \{Wei Che\} and Wang, \{Hung Chen\} and Kung, \{Chia Te\} and Cheng, \{Ben Chung\} and Su, \{Yu Jih\} and Su, \{Chih Min\} and Hsiao, \{Sheng Yuan\} and Lu, \{Cheng Hsien\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = aug,

doi = "10.1016/j.sleep.2019.03.017",

language = "英语",

volume = "60",

pages = "152--158",

journal = "Sleep Medicine",

issn = "1389-9457",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Long-term effects of surgical treatment on baroreflex function in patients with obstructive sleep apnea

T2 - an 18-month follow-up

AU - Huang, Chih Cheng

AU - Lin, Hsin Ching

AU - Lai, Yun Ru

AU - Tsai, Nai Wen

AU - Lin, Wei Che

AU - Wang, Hung Chen

AU - Kung, Chia Te

AU - Cheng, Ben Chung

AU - Su, Yu Jih

AU - Su, Chih Min

AU - Hsiao, Sheng Yuan

AU - Lu, Cheng Hsien

PY - 2019/8

Y1 - 2019/8

N2 - Objective: Depressed baroreflex sensitivity (BRS) is reported in obstructive sleep apnea (OSA). Improvement of BRS short-term after surgical treatment is also reported. We tested the hypothesis that surgical treatment not only improves clinical outcomes, but also improves BRS after 18 months. Methods: Cardiovascular autonomic tests, polysomnography (PSG), and biochemical testing were prospectively evaluated in 54 OSA patients at three time points (preoperatively, 6 months and 18 months postoperatively) and compared with 20, age- and body mass index (BMI)-matched, healthy controls. Results: The BRS increased after surgical treatment at 18-month follow-up, with results similar to the healthy control. Additionally, average O2, mO2 <90% (% per night), and lowest O2 showed an increase after surgical treatment at the 18-month follow-up. Conclusions: Besides improvement in clinical outcomes, depressed BRS in OSA patients is reversible and these patients have the potential for total recovery of baroreflex function after 18 months of treatment.

AB - Objective: Depressed baroreflex sensitivity (BRS) is reported in obstructive sleep apnea (OSA). Improvement of BRS short-term after surgical treatment is also reported. We tested the hypothesis that surgical treatment not only improves clinical outcomes, but also improves BRS after 18 months. Methods: Cardiovascular autonomic tests, polysomnography (PSG), and biochemical testing were prospectively evaluated in 54 OSA patients at three time points (preoperatively, 6 months and 18 months postoperatively) and compared with 20, age- and body mass index (BMI)-matched, healthy controls. Results: The BRS increased after surgical treatment at 18-month follow-up, with results similar to the healthy control. Additionally, average O2, mO2 <90% (% per night), and lowest O2 showed an increase after surgical treatment at the 18-month follow-up. Conclusions: Besides improvement in clinical outcomes, depressed BRS in OSA patients is reversible and these patients have the potential for total recovery of baroreflex function after 18 months of treatment.

KW - Baroreflex sensitivity

KW - Long-term effects

KW - Obstructive sleep apnea

KW - Surgical outcome

UR - https://www.scopus.com/pages/publications/85066442022

U2 - 10.1016/j.sleep.2019.03.017

DO - 10.1016/j.sleep.2019.03.017

M3 - 文章

C2 - 31175049

AN - SCOPUS:85066442022

SN - 1389-9457

VL - 60

SP - 152

EP - 158

JO - Sleep Medicine

JF - Sleep Medicine

ER -

Long-term effects of surgical treatment on baroreflex function in patients with obstructive sleep apnea: an 18-month follow-up

Abstract

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Keywords

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