Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats

Li Zhang; Laura Liu; Ann L. Philip; Juan C. Martinez; Juan C. Guttierez; Mathieu Marella; Gaurav Patki; Akemi Matsuno-Yagi; Takao Yagi; Biju B. Thomas

doi:10.1016/j.neulet.2014.12.004

Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats

Li Zhang, Laura Liu, Ann L. Philip, Juan C. Martinez, Juan C. Guttierez, Mathieu Marella, Gaurav Patki, Akemi Matsuno-Yagi, Takao Yagi, Biju B. Thomas^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

Leber's hereditary optic neuropathy (LHON) is an inherited disorder affecting the retinal ganglion cells (RGCs) and their axons that lead to the loss of central vision. This study is aimed at evaluating the LHON symptoms in rats administered with rotenone microspheres into the superior colliculus (SC). Optical coherence tomography (OCT) analysis showed substantial loss of retinal nerve fiber layer (RNFL) thickness in rotenone injected rats. Optokinetic testing in rotenone treated rats showed decrease in head-tracking response. Electrophysiological mapping of the SC surface demonstrated attenuation of visually evoked responses; however, no changes were observed in the ERG data. The progressive pattern of disease manifestation in rotenone administered rats demonstrated several similarities with human disease symptoms. These rats with LHON-like symptoms can serve as a model for future investigators to design and implement reliable tests to assess the beneficial effects of therapeutic interventions for LHON disease.

Original language	English
Pages (from-to)	171-176
Number of pages	6
Journal	Neuroscience Letters
Volume	585
DOIs	https://doi.org/10.1016/j.neulet.2014.12.004
State	Published - 02 01 2015

Bibliographical note

Publisher Copyright:
© 2014.

Keywords

Animal model
Leber'
Rotenone
S hereditary optic neuropathy
Superior colliculus
Visual function

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10.1016/j.neulet.2014.12.004

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title = "Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats",

abstract = "Leber's hereditary optic neuropathy (LHON) is an inherited disorder affecting the retinal ganglion cells (RGCs) and their axons that lead to the loss of central vision. This study is aimed at evaluating the LHON symptoms in rats administered with rotenone microspheres into the superior colliculus (SC). Optical coherence tomography (OCT) analysis showed substantial loss of retinal nerve fiber layer (RNFL) thickness in rotenone injected rats. Optokinetic testing in rotenone treated rats showed decrease in head-tracking response. Electrophysiological mapping of the SC surface demonstrated attenuation of visually evoked responses; however, no changes were observed in the ERG data. The progressive pattern of disease manifestation in rotenone administered rats demonstrated several similarities with human disease symptoms. These rats with LHON-like symptoms can serve as a model for future investigators to design and implement reliable tests to assess the beneficial effects of therapeutic interventions for LHON disease.",

keywords = "Animal model, Leber', Rotenone, S hereditary optic neuropathy, Superior colliculus, Visual function",

author = "Li Zhang and Laura Liu and Philip, {Ann L.} and Martinez, {Juan C.} and Guttierez, {Juan C.} and Mathieu Marella and Gaurav Patki and Akemi Matsuno-Yagi and Takao Yagi and Thomas, {Biju B.}",

note = "Publisher Copyright: {\textcopyright} 2014.",

year = "2015",

month = jan,

day = "2",

doi = "10.1016/j.neulet.2014.12.004",

language = "英语",

volume = "585",

pages = "171--176",

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AU - Zhang, Li

AU - Liu, Laura

AU - Philip, Ann L.

AU - Martinez, Juan C.

AU - Guttierez, Juan C.

AU - Marella, Mathieu

AU - Patki, Gaurav

AU - Matsuno-Yagi, Akemi

AU - Yagi, Takao

AU - Thomas, Biju B.

PY - 2015/1/2

Y1 - 2015/1/2

N2 - Leber's hereditary optic neuropathy (LHON) is an inherited disorder affecting the retinal ganglion cells (RGCs) and their axons that lead to the loss of central vision. This study is aimed at evaluating the LHON symptoms in rats administered with rotenone microspheres into the superior colliculus (SC). Optical coherence tomography (OCT) analysis showed substantial loss of retinal nerve fiber layer (RNFL) thickness in rotenone injected rats. Optokinetic testing in rotenone treated rats showed decrease in head-tracking response. Electrophysiological mapping of the SC surface demonstrated attenuation of visually evoked responses; however, no changes were observed in the ERG data. The progressive pattern of disease manifestation in rotenone administered rats demonstrated several similarities with human disease symptoms. These rats with LHON-like symptoms can serve as a model for future investigators to design and implement reliable tests to assess the beneficial effects of therapeutic interventions for LHON disease.

AB - Leber's hereditary optic neuropathy (LHON) is an inherited disorder affecting the retinal ganglion cells (RGCs) and their axons that lead to the loss of central vision. This study is aimed at evaluating the LHON symptoms in rats administered with rotenone microspheres into the superior colliculus (SC). Optical coherence tomography (OCT) analysis showed substantial loss of retinal nerve fiber layer (RNFL) thickness in rotenone injected rats. Optokinetic testing in rotenone treated rats showed decrease in head-tracking response. Electrophysiological mapping of the SC surface demonstrated attenuation of visually evoked responses; however, no changes were observed in the ERG data. The progressive pattern of disease manifestation in rotenone administered rats demonstrated several similarities with human disease symptoms. These rats with LHON-like symptoms can serve as a model for future investigators to design and implement reliable tests to assess the beneficial effects of therapeutic interventions for LHON disease.

KW - Animal model

KW - Leber'

KW - Rotenone

KW - S hereditary optic neuropathy

KW - Superior colliculus

KW - Visual function

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U2 - 10.1016/j.neulet.2014.12.004

DO - 10.1016/j.neulet.2014.12.004

M3 - 文章

C2 - 25481764

AN - SCOPUS:84918830317

SN - 0304-3940

VL - 585

SP - 171

EP - 176

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats

Abstract

Bibliographical note

Keywords

UN SDGs

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