Long-term outcome of pregnancy complicating with severe aplastic anemia under supportive care

Kuan Ju Chen, Yao Lung Chang, Horng Chang, Shen Yuan Su, Hsiu Huei Peng, Shuenn Dyh Chang, An Shine Chao*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

6 Scopus citations


Objectives Pregnancy associated with aplastic anemia (AA) is a rare and heterogeneous disorder. We aimed to identify and evaluate the maternal and pregnant outcomes of pregnancy-associated severe AA treated with supportive care. Materials and methods A 25-year retrospective study was conducted at in a single center between 1990 and 2014 with pregnancy associated severe AA. In addition, relevant published cases of antenatally diagnosed pregnancy-associated severe AA after 1990 were identified by PubMed. The main goal was to determine the impact of various risk factors on maternal and fetal outcomes. Results 15 women with 18 pregnancies were enrolled. With addition of the published reports in literature, a total of 36 cases were included for reference review. Univariate analysis showed that low platelet counts (<2.0 × 109/L), bone marrow hypocellularity (<25%), and late diagnosis during pregnancy were predictors of poor maternal outcomes (P < 0.05). The complication rate of pregnancy outcomes was 53.3%, including preterm delivery, small gestational age (SGA), preterm premature ruptured of membranes (PPROM) and preeclampsia. Conclusions This study identified the risk factors of mortality and morbidity in pregnant women with severe AA, as well as the obstetrical complications associated with neonatal outcome.

Original languageEnglish
Pages (from-to)632-635
Number of pages4
JournalTaiwanese Journal of Obstetrics and Gynecology
Issue number5
StatePublished - 10 2017

Bibliographical note

Publisher Copyright:
© 2017


  • Aplastic anemia
  • Morbidity
  • Pregnancy


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