Long-term progression in chronic manganism: Ten years of follow-up

C. C. Huang; N. S. Chu; C. S. Lu; R. S. Chen; D. B. Calne

doi:10.1212/WNL.50.3.698

Long-term progression in chronic manganism: Ten years of follow-up

C. C. Huang^*, N. S. Chu, C. S. Lu, R. S. Chen, D. B. Calne

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

136 Scopus citations

Abstract

We studied the long-term clinical course of five patients with chronic manganese intoxication. The mean scores of the King's College Hospital Rating Scale for Parkinson's disease increased from 15.0 ± 4.2 in 1987 to 28.3 ± 6.70 in 1991 and then to 38.1 ± 12.9 in 1995. The deterioration was most prominent in gait, rigidity, speed of foot tapping, and writing. Tissue concentrations of manganese in blood, urine, scalp hair, and pubic hair returned to normal. Follow-up MRIs did not show paramagnetic high-signal intensity on T1-weighted images. The data indicate that clinical progression in patients with manganese parkinsonism continues even 10 years after cessation of exposure.

Original language	English
Pages (from-to)	698-700
Number of pages	3
Journal	Neurology
Volume	50
Issue number	3
DOIs	https://doi.org/10.1212/WNL.50.3.698
State	Published - 03 1998
Externally published	Yes

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title = "Long-term progression in chronic manganism: Ten years of follow-up",

abstract = "We studied the long-term clinical course of five patients with chronic manganese intoxication. The mean scores of the King's College Hospital Rating Scale for Parkinson's disease increased from 15.0 ± 4.2 in 1987 to 28.3 ± 6.70 in 1991 and then to 38.1 ± 12.9 in 1995. The deterioration was most prominent in gait, rigidity, speed of foot tapping, and writing. Tissue concentrations of manganese in blood, urine, scalp hair, and pubic hair returned to normal. Follow-up MRIs did not show paramagnetic high-signal intensity on T1-weighted images. The data indicate that clinical progression in patients with manganese parkinsonism continues even 10 years after cessation of exposure.",

author = "Huang, {C. C.} and Chu, {N. S.} and Lu, {C. S.} and Chen, {R. S.} and Calne, {D. B.}",

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AU - Huang, C. C.

AU - Chu, N. S.

AU - Lu, C. S.

AU - Chen, R. S.

AU - Calne, D. B.

PY - 1998/3

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N2 - We studied the long-term clinical course of five patients with chronic manganese intoxication. The mean scores of the King's College Hospital Rating Scale for Parkinson's disease increased from 15.0 ± 4.2 in 1987 to 28.3 ± 6.70 in 1991 and then to 38.1 ± 12.9 in 1995. The deterioration was most prominent in gait, rigidity, speed of foot tapping, and writing. Tissue concentrations of manganese in blood, urine, scalp hair, and pubic hair returned to normal. Follow-up MRIs did not show paramagnetic high-signal intensity on T1-weighted images. The data indicate that clinical progression in patients with manganese parkinsonism continues even 10 years after cessation of exposure.

AB - We studied the long-term clinical course of five patients with chronic manganese intoxication. The mean scores of the King's College Hospital Rating Scale for Parkinson's disease increased from 15.0 ± 4.2 in 1987 to 28.3 ± 6.70 in 1991 and then to 38.1 ± 12.9 in 1995. The deterioration was most prominent in gait, rigidity, speed of foot tapping, and writing. Tissue concentrations of manganese in blood, urine, scalp hair, and pubic hair returned to normal. Follow-up MRIs did not show paramagnetic high-signal intensity on T1-weighted images. The data indicate that clinical progression in patients with manganese parkinsonism continues even 10 years after cessation of exposure.

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Long-term progression in chronic manganism: Ten years of follow-up

Abstract

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