Long term survival in patients with hepatocellular carcinoma directly invading the gastrointestinal tract: Case reports and literature review

Ting Lung Lin, Anthony Q. Yap, Jing Houng Wang, Chao Long Chen, Shridhar G. Iyer, Jee Keem Low, Chih Che Lin, Wei Feng Li, Ta Yi Chen, Dibyajyoti Bora, Chih Yun Lin, Chih Chi Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) directly invading the gastrointestinal (GI) organs is rare and is associated with poor survival outcome. We report two patients with good long-term outcome following resection of HCC that invaded the stomach and duodenum, respectively. A literature review was conducted to elucidate the course of patients with this pathology. Two cases (57-year-old and 72-year-old males) with enlarged hepatic tumors directly invading the stomach and duodenum underwent hepatectomies with en-bloc resection of the involved organs. Both patients are still alive at 80 and 68 months following the surgery. Our literature review showed that most of the patients with this pathology have manifested, and died of persistent GI bleeding. Patients who were treated surgically had a statistically significant longer survival than those who were treated with non-surgical palliative treatments (P < 0.001). In addition, patients who were treated with surgery with curative intent tend to have a longer survival times than those who were treated with surgery to palliate the bleeding but the difference was not statistically significant (P < 0.174). Removing the tumor completely could significantly prolong the survival of patients with HCC invading the GI tract.

Original languageEnglish
Pages (from-to)e207-e214
JournalSurgical Oncology
Volume20
Issue number4
DOIs
StatePublished - 12 2011

Keywords

  • Direct invasion
  • Gastrointestinal tract
  • Hepatocellular carcinoma
  • Survival
  • Tumor bleed

Fingerprint

Dive into the research topics of 'Long term survival in patients with hepatocellular carcinoma directly invading the gastrointestinal tract: Case reports and literature review'. Together they form a unique fingerprint.

Cite this