TY - JOUR
T1 - Longer Dialysis Times Are Associated With a Lower Chance of Dementia Among Chronic Hemodialysis Patients
AU - Chou, Che Yi
AU - Wu, Tai Te
AU - Chang, Chieh Ying
AU - Chen, Tzu Jen
AU - Chang, Chiz Tzung
AU - Huang, Chiu Ching
N1 - Publisher Copyright:
© 2014 International Society for Apheresis.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Dementia is common in chronic hemodialysis (HD) patients and is associated with a higher mortality. Factors associated with dementia in HD patients are not clear. We investigated factors associated with early dementia in HD patients. Chronic HD patients of 27 hemodialysis centers were enrolled in 2013. Early dementia was identified using the AD8 assessment. Factors associated with early dementia were analyzed using logistic regression. A total of 1617 chronic HD patients including 820 males and 797 females, aged 63.3±13 years, dialyzed for 4 (1.8-8.4) years were analyzed. Early dementia was identified in 414 (25.6%) of the patients. Longer HD times were associated with a lower chance of dementia (P=0.032), with an adjusted odds ratio (OR) of 0.522 (95% confidence interval [CI]: 0.270-0.969) for every one more hour of HD. Patient's age (OR: 1.587, 95% CI: 1.406-1.791, P<0.001), body mass index (OR: 0.958, 95% CI: 0.921-0.996, P=0.031), cerebrovascular accident (OR: 1.480, 95% CI: 1.000-2.188), diabetes (OR: 1.894, 95% CI: 1.390-2.581, P<0.001), and serum albumin (OR: 0.376, 95 % CI: 0.256-0.553, P<0.001) were independently linked to early dementia. Short hemodialysis times are associated with early dementia in a chronic hemodialysis population with a quarter of patients having early dementia. Patients' age, nutrition status and comorbidity are independently linked to early dementia.
AB - Dementia is common in chronic hemodialysis (HD) patients and is associated with a higher mortality. Factors associated with dementia in HD patients are not clear. We investigated factors associated with early dementia in HD patients. Chronic HD patients of 27 hemodialysis centers were enrolled in 2013. Early dementia was identified using the AD8 assessment. Factors associated with early dementia were analyzed using logistic regression. A total of 1617 chronic HD patients including 820 males and 797 females, aged 63.3±13 years, dialyzed for 4 (1.8-8.4) years were analyzed. Early dementia was identified in 414 (25.6%) of the patients. Longer HD times were associated with a lower chance of dementia (P=0.032), with an adjusted odds ratio (OR) of 0.522 (95% confidence interval [CI]: 0.270-0.969) for every one more hour of HD. Patient's age (OR: 1.587, 95% CI: 1.406-1.791, P<0.001), body mass index (OR: 0.958, 95% CI: 0.921-0.996, P=0.031), cerebrovascular accident (OR: 1.480, 95% CI: 1.000-2.188), diabetes (OR: 1.894, 95% CI: 1.390-2.581, P<0.001), and serum albumin (OR: 0.376, 95 % CI: 0.256-0.553, P<0.001) were independently linked to early dementia. Short hemodialysis times are associated with early dementia in a chronic hemodialysis population with a quarter of patients having early dementia. Patients' age, nutrition status and comorbidity are independently linked to early dementia.
KW - Chronic kidney disease
KW - Early dementia
KW - Hemodialysis
KW - Nutrition
UR - http://www.scopus.com/inward/record.url?scp=84922663286&partnerID=8YFLogxK
U2 - 10.1111/1744-9987.12220
DO - 10.1111/1744-9987.12220
M3 - 文章
C2 - 25196986
AN - SCOPUS:84922663286
SN - 1744-9979
VL - 19
SP - 50
EP - 55
JO - Therapeutic Apheresis and Dialysis
JF - Therapeutic Apheresis and Dialysis
IS - 1
ER -