LONGITUDINAL CHANGES IN CHOROIDAL THICKNESS IN CHILDREN WITH A HISTORY OF PREMATURITY: An 18-Month Prospective Cohort Study

Yung Sung Lee; Laura Liu; Nan Kai Wang; Kuan Jen Chen; Yih Shiou Hwang; Chi Chun Lai; Wei Chi Wu

doi:10.1097/IAE.0000000000004062

LONGITUDINAL CHANGES IN CHOROIDAL THICKNESS IN CHILDREN WITH A HISTORY OF PREMATURITY: An 18-Month Prospective Cohort Study

Yung Sung Lee, Laura Liu, Nan Kai Wang, Kuan Jen Chen, Yih Shiou Hwang, Chi Chun Lai, Wei Chi Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

PURPOSE: To evaluate choroidal changes over time in school-age children with a history of prematurity.

METHODS: A study of 416 eyes of 208 eligible participants, including 88, 190, 36, 56, and 46 eyes in the full-term control, preterm, spontaneously regressed retinopathy of prematurity, intravitreal bevacizumab (injection of bevacizumab)-treated retinopathy of prematurity, and laser-treated retinopathy of prematurity groups, respectively, were enrolled in this study. The choroidal thickness was measured 4 times at 6-month intervals using optical coherence tomography.

RESULTS: Of all the groups, the laser-treated children had the thinnest choroid compared with full-term children (-52.3 µ m, P = 0.04). Preterm children exhibited greater attenuation in choroidal thickness over time than did full-term children (-6.3 ± 26.9 and -1.1 ± 12.8 µ m/year, P = 0.03), whereas no difference was observed between injection of bevacizumab and laser treatments (-4.6 ± 18.9 and -2.0 ± 15.7 µ m/year, P = 0.46). In all groups, the changes in axial length were negatively associated with the changes in choroidal thickness (all P < 0.05).

CONCLUSION: A greater attenuation in choroid thickness over time was observed in preterm children than in full-term children, but this attenuation did not differ between injection of bevacizumab and laser treatments. Axial elongation was associated with choroidal thinning in school-age children.

Original language	English
Pages (from-to)	1063-1072
Number of pages	10
Journal	Retina
Volume	44
Issue number	6
DOIs	https://doi.org/10.1097/IAE.0000000000004062
State	Published - 01 06 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© by Ophthalmic Communications Society, Inc.

Keywords

anti–vascular endothelial growth factor
choroidal thickness
laser photocoagulation
prematurity
retinopathy of prematurity
Prospective Studies
Bevacizumab/administration & dosage
Intravitreal Injections
Follow-Up Studies
Humans
Male
Choroid/pathology
Visual Acuity
Gestational Age
Retinopathy of Prematurity/diagnosis
Infant, Premature
Laser Coagulation/methods
Tomography, Optical Coherence/methods
Female
Angiogenesis Inhibitors/administration & dosage
Vascular Endothelial Growth Factor A/antagonists & inhibitors
Child
Infant, Newborn

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10.1097/IAE.0000000000004062

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@article{440e2d51e00245a5b39e4efe3cc29b5a,

title = "LONGITUDINAL CHANGES IN CHOROIDAL THICKNESS IN CHILDREN WITH A HISTORY OF PREMATURITY: An 18-Month Prospective Cohort Study",

abstract = "PURPOSE: To evaluate choroidal changes over time in school-age children with a history of prematurity.METHODS: A study of 416 eyes of 208 eligible participants, including 88, 190, 36, 56, and 46 eyes in the full-term control, preterm, spontaneously regressed retinopathy of prematurity, intravitreal bevacizumab (injection of bevacizumab)-treated retinopathy of prematurity, and laser-treated retinopathy of prematurity groups, respectively, were enrolled in this study. The choroidal thickness was measured 4 times at 6-month intervals using optical coherence tomography.RESULTS: Of all the groups, the laser-treated children had the thinnest choroid compared with full-term children (-52.3 µ m, P = 0.04). Preterm children exhibited greater attenuation in choroidal thickness over time than did full-term children (-6.3 ± 26.9 and -1.1 ± 12.8 µ m/year, P = 0.03), whereas no difference was observed between injection of bevacizumab and laser treatments (-4.6 ± 18.9 and -2.0 ± 15.7 µ m/year, P = 0.46). In all groups, the changes in axial length were negatively associated with the changes in choroidal thickness (all P < 0.05).CONCLUSION: A greater attenuation in choroid thickness over time was observed in preterm children than in full-term children, but this attenuation did not differ between injection of bevacizumab and laser treatments. Axial elongation was associated with choroidal thinning in school-age children.",

keywords = "anti–vascular endothelial growth factor, choroidal thickness, laser photocoagulation, prematurity, retinopathy of prematurity, Prospective Studies, Bevacizumab/administration \& dosage, Intravitreal Injections, Follow-Up Studies, Humans, Male, Choroid/pathology, Visual Acuity, Gestational Age, Retinopathy of Prematurity/diagnosis, Infant, Premature, Laser Coagulation/methods, Tomography, Optical Coherence/methods, Female, Angiogenesis Inhibitors/administration \& dosage, Vascular Endothelial Growth Factor A/antagonists \& inhibitors, Child, Infant, Newborn",

author = "Lee, \{Yung Sung\} and Laura Liu and Wang, \{Nan Kai\} and Chen, \{Kuan Jen\} and Hwang, \{Yih Shiou\} and Lai, \{Chi Chun\} and Wu, \{Wei Chi\}",

note = "Publisher Copyright: {\textcopyright} by Ophthalmic Communications Society, Inc.",

year = "2024",

month = jun,

day = "1",

doi = "10.1097/IAE.0000000000004062",

language = "英语",

volume = "44",

pages = "1063--1072",

journal = "Retina",

issn = "0275-004X",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

TY - JOUR

T1 - LONGITUDINAL CHANGES IN CHOROIDAL THICKNESS IN CHILDREN WITH A HISTORY OF PREMATURITY

T2 - An 18-Month Prospective Cohort Study

AU - Lee, Yung Sung

AU - Liu, Laura

AU - Wang, Nan Kai

AU - Chen, Kuan Jen

AU - Hwang, Yih Shiou

AU - Lai, Chi Chun

AU - Wu, Wei Chi

N1 - Publisher Copyright: © by Ophthalmic Communications Society, Inc.

PY - 2024/6/1

Y1 - 2024/6/1

N2 - PURPOSE: To evaluate choroidal changes over time in school-age children with a history of prematurity.METHODS: A study of 416 eyes of 208 eligible participants, including 88, 190, 36, 56, and 46 eyes in the full-term control, preterm, spontaneously regressed retinopathy of prematurity, intravitreal bevacizumab (injection of bevacizumab)-treated retinopathy of prematurity, and laser-treated retinopathy of prematurity groups, respectively, were enrolled in this study. The choroidal thickness was measured 4 times at 6-month intervals using optical coherence tomography.RESULTS: Of all the groups, the laser-treated children had the thinnest choroid compared with full-term children (-52.3 µ m, P = 0.04). Preterm children exhibited greater attenuation in choroidal thickness over time than did full-term children (-6.3 ± 26.9 and -1.1 ± 12.8 µ m/year, P = 0.03), whereas no difference was observed between injection of bevacizumab and laser treatments (-4.6 ± 18.9 and -2.0 ± 15.7 µ m/year, P = 0.46). In all groups, the changes in axial length were negatively associated with the changes in choroidal thickness (all P < 0.05).CONCLUSION: A greater attenuation in choroid thickness over time was observed in preterm children than in full-term children, but this attenuation did not differ between injection of bevacizumab and laser treatments. Axial elongation was associated with choroidal thinning in school-age children.

AB - PURPOSE: To evaluate choroidal changes over time in school-age children with a history of prematurity.METHODS: A study of 416 eyes of 208 eligible participants, including 88, 190, 36, 56, and 46 eyes in the full-term control, preterm, spontaneously regressed retinopathy of prematurity, intravitreal bevacizumab (injection of bevacizumab)-treated retinopathy of prematurity, and laser-treated retinopathy of prematurity groups, respectively, were enrolled in this study. The choroidal thickness was measured 4 times at 6-month intervals using optical coherence tomography.RESULTS: Of all the groups, the laser-treated children had the thinnest choroid compared with full-term children (-52.3 µ m, P = 0.04). Preterm children exhibited greater attenuation in choroidal thickness over time than did full-term children (-6.3 ± 26.9 and -1.1 ± 12.8 µ m/year, P = 0.03), whereas no difference was observed between injection of bevacizumab and laser treatments (-4.6 ± 18.9 and -2.0 ± 15.7 µ m/year, P = 0.46). In all groups, the changes in axial length were negatively associated with the changes in choroidal thickness (all P < 0.05).CONCLUSION: A greater attenuation in choroid thickness over time was observed in preterm children than in full-term children, but this attenuation did not differ between injection of bevacizumab and laser treatments. Axial elongation was associated with choroidal thinning in school-age children.

KW - anti–vascular endothelial growth factor

KW - choroidal thickness

KW - laser photocoagulation

KW - prematurity

KW - retinopathy of prematurity

KW - Prospective Studies

KW - Bevacizumab/administration & dosage

KW - Intravitreal Injections

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Choroid/pathology

KW - Visual Acuity

KW - Gestational Age

KW - Retinopathy of Prematurity/diagnosis

KW - Infant, Premature

KW - Laser Coagulation/methods

KW - Tomography, Optical Coherence/methods

KW - Female

KW - Angiogenesis Inhibitors/administration & dosage

KW - Vascular Endothelial Growth Factor A/antagonists & inhibitors

KW - Child

KW - Infant, Newborn

UR - https://www.scopus.com/pages/publications/85193773957

U2 - 10.1097/IAE.0000000000004062

DO - 10.1097/IAE.0000000000004062

M3 - 文章

C2 - 38346114

AN - SCOPUS:85193773957

SN - 0275-004X

VL - 44

SP - 1063

EP - 1072

JO - Retina

JF - Retina

IS - 6

ER -

LONGITUDINAL CHANGES IN CHOROIDAL THICKNESS IN CHILDREN WITH A HISTORY OF PREMATURITY: An 18-Month Prospective Cohort Study

Abstract

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Keywords

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