Low baseline urine creatinine excretion rate predicts poor outcomes among critically Ill acute stroke patients

Chia Yu Hsu, Yi Ling Wu, Chun Yu Cheng, Jiann Der Lee, Ying Chih Huang, Ming Hsueh Lee, Chih Ying Wu, Huan Lin Hsu, Ya Hui Lin, Yen Chu Huang, Hsin Ta Yang, Jen Tsung Yang, Meng Lee*, Bruce Ovbiagele

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

8 Scopus citations


Urinary creatinine excretion rate (CER) is an established marker of muscle mass. Low CER has been linked to poor coronary artery disease outcomes, but a link between CER and acute stroke prognosis has not been previously explored. We prospectively collected data from patients with acute stroke (ischemic or hemorrhagic) within 24 hours from symptom onset in a Neurological and Neurosurgery Intensive Care Unit in Taiwan. Baseline CER (mg/d) was calculated by urine creatinine concentration in morning spot urine multiplies 24-hour urine volume on the second day of admission. Patients were divided into 3 tertiles with highest, middle, and lowest CER. Primary endpoint was poor outcome defined as modified Rankin Scale 3-6 at 6 months. Among 156 critically ill acute stroke patients meeting study entry criteria, average age was 67.9 years, and 83 (53.2%) patients had ischemic stroke. Patients with lowest CER (vs. highest CER) had a high risk of poor outcome at 6-month after adjustment (odds ratio 4.96, 95% confidence interval 1.22 to 20.15, p value = 0.025). In conclusion, low baseline CER, a marker of muscle mass, was independently associated with poor 6-month outcome among critically ill acute stroke patients. We speculate that preservation of muscle mass through exercise or protein-energy supplement might be helpful for improving prognosis in severe stroke patients.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalCurrent Neurovascular Research
Issue number1
StatePublished - 01 01 2015

Bibliographical note

Publisher Copyright:
© 2015 Bentham Science Publishers.


  • Critically ill
  • Outcome
  • Stroke
  • Urine creatinine excretion rate


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