Abstract
Objective: The present retrospective and controlled comparative study was designed to evaluate the pregnancy rate achieved using a modified, fixed, multiple-dose 0.125. mg gonadotropin-releasing hormone (GnRH) antagonist protocol with the long GnRH agonist protocol as the control group. Materials and methods: One hundred and twenty unselected women between 30 and 40 years of age, in their first cycle of IVF/ICSI, with a baseline follicle-stimulating hormone (FSH) <10 IU and an antral follicle count >3 were assigned into two groups: (1) the study group received 0.125. mg of cetrorelix daily starting on Day 6 of stimulation; and (2) the control group received leuprolide daily starting in the mid-luteal phase of the preceding cycle. Both groups were given a flexible dose of recombinant FSH for stimulation. An ongoing pregnancy rate of more than 12 weeks was the primary outcome measure of the study. Results: Primary and secondary outcomes were comparable in both groups. A shorter duration of stimulation, a lower dosage of recombinant FSH consumption and a thinner endometrium on the day of human chorionic gonadotropin administration were all observed in the GnRH antagonist group. Conclusion: A dosage of 0.125. mg GnRH antagonist protocol was effective for these unselected patients during IVF/ET.
Original language | English |
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Pages (from-to) | 432-435 |
Number of pages | 4 |
Journal | Taiwanese Journal of Obstetrics and Gynecology |
Volume | 50 |
Issue number | 4 |
DOIs | |
State | Published - 12 2011 |
Keywords
- GnRH antagonist
- Long protocol
- Modified flexible multiple-dose regimen
- Pregnancy rate