Low FCMR mRNA expression in leukocytes of patients with Kawasaki disease six months after disease onset

Ling Sai Chang, Mindy Ming Huey Guo, Jia Huei Yan, Ying Hsien Huang, Mao Hung Lo, Ho Chang Kuo*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

8 Scopus citations


Background: Immunoglobulin (Ig) M plays an important role in immune regulation. FCMR-encoded FcμR is a receptor of IgM. Previous research has suggested that IgM levels may be involved in the coronary artery lesions of Kawasaki syndrome or Kawasaki disease (KD). In this study, we aimed to explore the roles of mRNA expressions of IgM receptors, particularly FCMR, in KD patients. FCMR encodes the Fc fragment of immunoglobulin M receptor. Methods: We enrolled 60 KD patients and 55 non-KD controls. Whole-blood leukocytes were isolated, and the mRNA expression for FCMR was determined. Each mRNA consisted of a sample taken before intravenous immunoglobulin (IVIG) was administered (acute, KD1) and those taken at three weeks, six months, and one year later (KD3, KD4, KD5). Paired KD subjects were analyzed from both the acute and convalescent phases (n = 28). Results: After six months and one year of treatment, KD patients still apparently have lower FCMR compared with controls (P =.004). FCMR expressions were downregulated in male patients with KD prior to IVIG administration (P =.044). The FCMR of paired KD patients who received IVIG treatments after six months was significantly lower than before undergoing IVIG treatment (P =.044). Expressions in the polymorphonuclear leukocytes were similar to those in the peripheral blood mononuclear cells. Conclusion: The unique data supported that FCMR is expressed by granulocytes at RNA levels in humans and demonstrated lower FCMR six months after the onset of KD. The findings remind us of the need to track the health of children with KD over the long term, even if we think patients have fully recovered.

Original languageEnglish
Pages (from-to)554-559
Number of pages6
JournalPediatric Allergy and Immunology
Issue number5
StatePublished - 01 07 2020

Bibliographical note

Publisher Copyright:
© 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.


  • FCMR
  • IVIG resistance
  • Kawasaki disease
  • coronary artery lesions
  • immunoglobulin M


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