Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al

I. Hsiao Chen, Ying Chi Du, Mei Chin Lu, An Shen Lin, Pei Wen Hsieh, Chin Chung Wu, Shu Li Chen, Hsin Fu Yen, Fang Rong Chang*, Yang Chang Wu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

34 Scopus citations

Abstract

Seven new lupane triterpenoids were isolated from bioactive methanol extracts of Microtropis fokienensis (1-4) and Perrottetia arisanensis (4-7), along with 18 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data analysis. All triterpenoids were evaluated for their in vitro cytotoxicity toward seven human cancer cell lines. Compound 8 (28-hydroxy-3-oxo-lup-20(29)-en-30-al) was among the most cytotoxic substances obtained and was found to induce apoptosis of human leukemia HL60 cells and mediate cleavage of PARP and up-regulation of Bax proteins.

Original languageEnglish
Pages (from-to)1352-1357
Number of pages6
JournalJournal of Natural Products
Volume71
Issue number8
DOIs
StatePublished - 08 2008
Externally publishedYes

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