Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al

I. Hsiao Chen; Ying Chi Du; Mei Chin Lu; An Shen Lin; Pei Wen Hsieh; Chin Chung Wu; Shu Li Chen; Hsin Fu Yen; Fang Rong Chang; Yang Chang Wu

doi:10.1021/np800093a

Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al

I. Hsiao Chen
, Ying Chi Du
, Mei Chin Lu
, An Shen Lin
, Pei Wen Hsieh
, Chin Chung Wu
, Shu Li Chen
, Hsin Fu Yen
, Fang Rong Chang^*
, Yang Chang Wu

^*Corresponding author for this work

Kaohsiung Medical University
National Museum of Natural Science, Taiwan
National Sun Yat-sen University

Research output: Contribution to journal › Journal Article › peer-review

34 Scopus citations

Abstract

Seven new lupane triterpenoids were isolated from bioactive methanol extracts of Microtropis fokienensis (1-4) and Perrottetia arisanensis (4-7), along with 18 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data analysis. All triterpenoids were evaluated for their in vitro cytotoxicity toward seven human cancer cell lines. Compound 8 (28-hydroxy-3-oxo-lup-20(29)-en-30-al) was among the most cytotoxic substances obtained and was found to induce apoptosis of human leukemia HL60 cells and mediate cleavage of PARP and up-regulation of Bax proteins.

Original language	English
Pages (from-to)	1352-1357
Number of pages	6
Journal	Journal of Natural Products
Volume	71
Issue number	8
DOIs	https://doi.org/10.1021/np800093a
State	Published - 08 2008
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1021/np800093a

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title = "Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al",

abstract = "Seven new lupane triterpenoids were isolated from bioactive methanol extracts of Microtropis fokienensis (1-4) and Perrottetia arisanensis (4-7), along with 18 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data analysis. All triterpenoids were evaluated for their in vitro cytotoxicity toward seven human cancer cell lines. Compound 8 (28-hydroxy-3-oxo-lup-20(29)-en-30-al) was among the most cytotoxic substances obtained and was found to induce apoptosis of human leukemia HL60 cells and mediate cleavage of PARP and up-regulation of Bax proteins.",

author = "Chen, \{I. Hsiao\} and Du, \{Ying Chi\} and Lu, \{Mei Chin\} and Lin, \{An Shen\} and Hsieh, \{Pei Wen\} and Wu, \{Chin Chung\} and Chen, \{Shu Li\} and Yen, \{Hsin Fu\} and Chang, \{Fang Rong\} and Wu, \{Yang Chang\}",

year = "2008",

month = aug,

doi = "10.1021/np800093a",

language = "英语",

volume = "71",

pages = "1352--1357",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al

AU - Chen, I. Hsiao

AU - Du, Ying Chi

AU - Lu, Mei Chin

AU - Lin, An Shen

AU - Hsieh, Pei Wen

AU - Wu, Chin Chung

AU - Chen, Shu Li

AU - Yen, Hsin Fu

AU - Chang, Fang Rong

AU - Wu, Yang Chang

PY - 2008/8

Y1 - 2008/8

N2 - Seven new lupane triterpenoids were isolated from bioactive methanol extracts of Microtropis fokienensis (1-4) and Perrottetia arisanensis (4-7), along with 18 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data analysis. All triterpenoids were evaluated for their in vitro cytotoxicity toward seven human cancer cell lines. Compound 8 (28-hydroxy-3-oxo-lup-20(29)-en-30-al) was among the most cytotoxic substances obtained and was found to induce apoptosis of human leukemia HL60 cells and mediate cleavage of PARP and up-regulation of Bax proteins.

AB - Seven new lupane triterpenoids were isolated from bioactive methanol extracts of Microtropis fokienensis (1-4) and Perrottetia arisanensis (4-7), along with 18 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data analysis. All triterpenoids were evaluated for their in vitro cytotoxicity toward seven human cancer cell lines. Compound 8 (28-hydroxy-3-oxo-lup-20(29)-en-30-al) was among the most cytotoxic substances obtained and was found to induce apoptosis of human leukemia HL60 cells and mediate cleavage of PARP and up-regulation of Bax proteins.

UR - https://www.scopus.com/pages/publications/51849157770

U2 - 10.1021/np800093a

DO - 10.1021/np800093a

M3 - 文章

C2 - 18590313

AN - SCOPUS:51849157770

SN - 0163-3864

VL - 71

SP - 1352

EP - 1357

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 8

ER -

Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al

Abstract

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