Lymph node ratio as a survival predictor for head and neck squamous cell carcinoma with multiple adverse pathological features

Ming Hsien Tsai; Hui Ching Chuang; Chih Yen Chien; Tai Lin Huang; Hui Lu; Yan Ye Su; Chao Hui Yang; Chi Chih Lai; Wen Ling Tsai; Yu Tsai Lin; Fu Min Fang

doi:10.1002/hed.27428

Lymph node ratio as a survival predictor for head and neck squamous cell carcinoma with multiple adverse pathological features

Ming Hsien Tsai
, Hui Ching Chuang
, Chih Yen Chien
, Tai Lin Huang
, Hui Lu
, Yan Ye Su
, Chao Hui Yang
, Chi Chih Lai
, Wen Ling Tsai
, Yu Tsai Lin^*
, Fu Min Fang^*

^*Corresponding author for this work

Chang Gung University
Chang Gung Memorial Hospital
Tajen University
Cheng Shiu University Taiwan

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

Background: The study investigates the prognostic significance of lymph node ratio (LNR) on patients with head and neck squamous cell carcinoma (HNSCC) with coexistence of multiple adverse pathological features. Methods: In total, 100 patients with coexistence of perineural invasion, lymphovascular invasion, and extranodal extension of first primary HNSCC treated with radical surgery followed by adjuvant chemoradiotherapy were enrolled. Results: The optimal LNR cut-off value for predicting overall survival (OS) and cancer specific survival (CSS) was 7%. In Cox model, we observed that LNR ≥7% was a statistically significant unfavorable predictor of OS (HR: 2.689; 95% CI: 1.228–5.889; p = 0.013) and CSS (HR: 3.162; 95% CI: 1.234–8.102; p = 0.016). Conclusion: For HNSCC patients with coexistence of multiple adverse pathological features, LNR is an independent survival predictor. Novel intensified treatments are needed for the subgroup of patients with a high LNR.

Original language	English
Pages (from-to)	2017-2027
Number of pages	11
Journal	Head and Neck
Volume	45
Issue number	8
DOIs	https://doi.org/10.1002/hed.27428
State	Published - 08 2023
Externally published	Yes

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

extranodal extension
head and neck squamous cell carcinoma
lymph node ratio
lymphovascular invasion
perineural invasion
Prognosis
Humans
Head and Neck Neoplasms/therapy
Carcinoma, Squamous Cell/pathology
Lymph Nodes/pathology
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck/therapy
Neoplasm Staging
Lymph Node Ratio

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10.1002/hed.27428

Cite this

@article{fd149d1c00074613ba7e8cf40a114afc,

title = "Lymph node ratio as a survival predictor for head and neck squamous cell carcinoma with multiple adverse pathological features",

abstract = "Background: The study investigates the prognostic significance of lymph node ratio (LNR) on patients with head and neck squamous cell carcinoma (HNSCC) with coexistence of multiple adverse pathological features. Methods: In total, 100 patients with coexistence of perineural invasion, lymphovascular invasion, and extranodal extension of first primary HNSCC treated with radical surgery followed by adjuvant chemoradiotherapy were enrolled. Results: The optimal LNR cut-off value for predicting overall survival (OS) and cancer specific survival (CSS) was 7\%. In Cox model, we observed that LNR ≥7\% was a statistically significant unfavorable predictor of OS (HR: 2.689; 95\% CI: 1.228{\textendash}5.889; p = 0.013) and CSS (HR: 3.162; 95\% CI: 1.234{\textendash}8.102; p = 0.016). Conclusion: For HNSCC patients with coexistence of multiple adverse pathological features, LNR is an independent survival predictor. Novel intensified treatments are needed for the subgroup of patients with a high LNR.",

keywords = "extranodal extension, head and neck squamous cell carcinoma, lymph node ratio, lymphovascular invasion, perineural invasion, Prognosis, Humans, Head and Neck Neoplasms/therapy, Carcinoma, Squamous Cell/pathology, Lymph Nodes/pathology, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck/therapy, Neoplasm Staging, Lymph Node Ratio",

author = "Tsai, \{Ming Hsien\} and Chuang, \{Hui Ching\} and Chien, \{Chih Yen\} and Huang, \{Tai Lin\} and Hui Lu and Su, \{Yan Ye\} and Yang, \{Chao Hui\} and Lai, \{Chi Chih\} and Tsai, \{Wen Ling\} and Lin, \{Yu Tsai\} and Fang, \{Fu Min\}",

note = "{\textcopyright} 2023 Wiley Periodicals LLC.",

year = "2023",

month = aug,

doi = "10.1002/hed.27428",

language = "英语",

volume = "45",

pages = "2017--2027",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

number = "8",

}

TY - JOUR

T1 - Lymph node ratio as a survival predictor for head and neck squamous cell carcinoma with multiple adverse pathological features

AU - Tsai, Ming Hsien

AU - Chuang, Hui Ching

AU - Chien, Chih Yen

AU - Huang, Tai Lin

AU - Lu, Hui

AU - Su, Yan Ye

AU - Yang, Chao Hui

AU - Lai, Chi Chih

AU - Tsai, Wen Ling

AU - Lin, Yu Tsai

AU - Fang, Fu Min

PY - 2023/8

Y1 - 2023/8

N2 - Background: The study investigates the prognostic significance of lymph node ratio (LNR) on patients with head and neck squamous cell carcinoma (HNSCC) with coexistence of multiple adverse pathological features. Methods: In total, 100 patients with coexistence of perineural invasion, lymphovascular invasion, and extranodal extension of first primary HNSCC treated with radical surgery followed by adjuvant chemoradiotherapy were enrolled. Results: The optimal LNR cut-off value for predicting overall survival (OS) and cancer specific survival (CSS) was 7%. In Cox model, we observed that LNR ≥7% was a statistically significant unfavorable predictor of OS (HR: 2.689; 95% CI: 1.228–5.889; p = 0.013) and CSS (HR: 3.162; 95% CI: 1.234–8.102; p = 0.016). Conclusion: For HNSCC patients with coexistence of multiple adverse pathological features, LNR is an independent survival predictor. Novel intensified treatments are needed for the subgroup of patients with a high LNR.

AB - Background: The study investigates the prognostic significance of lymph node ratio (LNR) on patients with head and neck squamous cell carcinoma (HNSCC) with coexistence of multiple adverse pathological features. Methods: In total, 100 patients with coexistence of perineural invasion, lymphovascular invasion, and extranodal extension of first primary HNSCC treated with radical surgery followed by adjuvant chemoradiotherapy were enrolled. Results: The optimal LNR cut-off value for predicting overall survival (OS) and cancer specific survival (CSS) was 7%. In Cox model, we observed that LNR ≥7% was a statistically significant unfavorable predictor of OS (HR: 2.689; 95% CI: 1.228–5.889; p = 0.013) and CSS (HR: 3.162; 95% CI: 1.234–8.102; p = 0.016). Conclusion: For HNSCC patients with coexistence of multiple adverse pathological features, LNR is an independent survival predictor. Novel intensified treatments are needed for the subgroup of patients with a high LNR.

KW - extranodal extension

KW - head and neck squamous cell carcinoma

KW - lymph node ratio

KW - lymphovascular invasion

KW - perineural invasion

KW - Prognosis

KW - Humans

KW - Head and Neck Neoplasms/therapy

KW - Carcinoma, Squamous Cell/pathology

KW - Lymph Nodes/pathology

KW - Retrospective Studies

KW - Squamous Cell Carcinoma of Head and Neck/therapy

KW - Neoplasm Staging

KW - Lymph Node Ratio

UR - https://www.scopus.com/pages/publications/85161714723

U2 - 10.1002/hed.27428

DO - 10.1002/hed.27428

M3 - 文章

C2 - 37296517

AN - SCOPUS:85161714723

SN - 1043-3074

VL - 45

SP - 2017

EP - 2027

JO - Head and Neck

JF - Head and Neck

IS - 8

ER -

Lymph node ratio as a survival predictor for head and neck squamous cell carcinoma with multiple adverse pathological features

Abstract

Bibliographical note

UN SDGs

Keywords

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