Lymphoproliferative disorder after liver transplantation

Po Ping Liu*, Chao Long Chen, Hock Liew Eng, Yaw Sen Chen, Yuan Cheng Chiang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

Lymphoproliferative disorder (LPD) is a well recognized complication of solid organ transplantation. It is associated with Epstein-Barr virus (EBV) infection and is often a fatal complication of immunosuppression. We report a 2.5-year-old boy who developed LPD presenting as small bowel lymphoma after liver transplantation. The patient had intermittent fever after transplantation and reactivation of latent EBV infection was documented by pre- and posttransplant serologic tests. About 5 months after his liver transplantation, the patient had sudden onset of abdominal pain and emergency laparotomy was performed for peritonitis. He proved to have multiple small bowel perforations caused by B cell lymphoma and died of multiple organ failure 9 days after operation, despite aggressive treatment and stopping immunosuppressive agents. We conclude that prevention of overimmuno-suppression in pediatric recipients after liver transplantation and early detection and treatment of LPD are important to decrease this often-fatal complication.

Original languageEnglish
Pages (from-to)59-62
Number of pages4
JournalJournal of the Formosan Medical Association
Volume97
Issue number1
StatePublished - 01 1998
Externally publishedYes

Keywords

  • Epstein-Barr virus
  • Liver transplantation
  • Lymphoproliferative disorder

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