Abstract
Lymphoproliferative disorder (LPD) is a well recognized complication of solid organ transplantation. It is associated with Epstein-Barr virus (EBV) infection and is often a fatal complication of immunosuppression. We report a 2.5-year-old boy who developed LPD presenting as small bowel lymphoma after liver transplantation. The patient had intermittent fever after transplantation and reactivation of latent EBV infection was documented by pre- and posttransplant serologic tests. About 5 months after his liver transplantation, the patient had sudden onset of abdominal pain and emergency laparotomy was performed for peritonitis. He proved to have multiple small bowel perforations caused by B cell lymphoma and died of multiple organ failure 9 days after operation, despite aggressive treatment and stopping immunosuppressive agents. We conclude that prevention of overimmuno-suppression in pediatric recipients after liver transplantation and early detection and treatment of LPD are important to decrease this often-fatal complication.
Original language | English |
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Pages (from-to) | 59-62 |
Number of pages | 4 |
Journal | Journal of the Formosan Medical Association |
Volume | 97 |
Issue number | 1 |
State | Published - 01 1998 |
Externally published | Yes |
Keywords
- Epstein-Barr virus
- Liver transplantation
- Lymphoproliferative disorder