Macrophage Class A Scavenger Receptors – A Functional Perspective

Siamon Gordon; Matthew W.H. Chung; Scarlett L. Harris; Fernando Martinez-Estrada; Subhankar Mukhopadhyay

doi:10.1016/B978-0-12-821618-7.00255-8

Macrophage Class A Scavenger Receptors – A Functional Perspective

Siamon Gordon, Matthew W.H. Chung, Scarlett L. Harris, Fernando Martinez-Estrada, Subhankar Mukhopadhyay

Graduate Institute of Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

As we approach the half century of the description of a macrophage clearance receptor for modified LDL by Brown and Goldstein, it is opportune to take stock of what we have learnt hitherto about the role of selected scavenger receptors in macrophage functions. Recent advances in genetic, temporal and spatial analysis of gene and protein expression have brought fresh opportunities to integrate and extend the present disparate observations in the literature. In this review, we focus on two Class A Scavenger Receptors, SR-A and MARCO, expressed almost exclusively by mononuclear phagocytes, and draw attention to their ongoing contributions to cell biology; we speculate on potential functions in macrophage pathophysiology and suggest possibilities for therapeutic manipulation.

Original language	English
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Volume 1-6, Second Edition
Publisher	Elsevier
Pages	644-661
Number of pages	18
Volume	5
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00255-8
State	Published - 01 01 2022

Bibliographical note

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Keywords

Class A Scavenger receptors
Epigenetics
Infection
Inflammation
Innate immunity
Ligand clearance
Lipid metabolism
MARCO
Macrophages
Malignancy
Microbial pathogens
Phagocytosis
Plasma membrane receptors
Receptor targeted therapy
SR
SR-A

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10.1016/B978-0-12-821618-7.00255-8

Cite this

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abstract = "As we approach the half century of the description of a macrophage clearance receptor for modified LDL by Brown and Goldstein, it is opportune to take stock of what we have learnt hitherto about the role of selected scavenger receptors in macrophage functions. Recent advances in genetic, temporal and spatial analysis of gene and protein expression have brought fresh opportunities to integrate and extend the present disparate observations in the literature. In this review, we focus on two Class A Scavenger Receptors, SR-A and MARCO, expressed almost exclusively by mononuclear phagocytes, and draw attention to their ongoing contributions to cell biology; we speculate on potential functions in macrophage pathophysiology and suggest possibilities for therapeutic manipulation.",

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KW - Inflammation

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KW - Ligand clearance

KW - Lipid metabolism

KW - MARCO

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KW - Malignancy

KW - Microbial pathogens

KW - Phagocytosis

KW - Plasma membrane receptors

KW - Receptor targeted therapy

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KW - SR-A

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PB - Elsevier

ER -

Macrophage Class A Scavenger Receptors – A Functional Perspective

Abstract

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Keywords

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