Macrophage phenotype in tumours

Hsi Hsien Lin; Siamon Gordon

doi:10.1007/978-1-4614-0662-4_1

Macrophage phenotype in tumours

Hsi Hsien Lin, Siamon Gordon^*

^*Corresponding author for this work

Department of Microbiology and Immunology

University of Oxford

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Macrophages are often present in tumours, display considerable heterogeneity in phenotype, and contribute trophic, tumour-promoting functions that favour clonal emergence, growth and spread of malignant cells, as well as contributing to host tolerance and stromal reactions. Membrane glycoproteins provide antigenic markers, serve as receptors for tumour-derived ligands, and regulate macrophage-tumour interactions. We review selected aspects of macrophage phenotypic heterogeneity, with special reference to novel markers such as the EGF-TM7 family of myeloid differentiation antigens. Improved characterisation of macrophage plasticity may make it possible to manipulate macrophage effector functions to the advantage of the host.

Original language	English
Title of host publication	Tumour-Associated Macrophages
Publisher	Springer New York
Pages	3-16
Number of pages	14
ISBN (Electronic)	9781461406624
ISBN (Print)	1461406617, 9781461406617
DOIs	https://doi.org/10.1007/978-1-4614-0662-4_1
State	Published - 01 05 2011

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© 2012 Springer Science+Business Media, LLC. All rights reserved.

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Macrophage phenotype in tumours

Abstract

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