Macrophages and microglia in the nervous system

V. Hugh Perry*, Siamon Gordon

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

682 Scopus citations


Why might macrophages be of interest to neurobiologists? Recent evidence shows that macrophages play a role in tissue homeostasis as well as in defence and repair of tissues. We will review here the possible functions of resident and recruited macrophages in the developing and adult nervous system and examine what contribution these cells might make to repair mechanisms in the central and peripheral nervous systems. There is increasing evidence that macrophages form an important component of the non-neuronal cell population in the nervous system and the tools are becoming available that allow us to study these cells in situ.

Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalTrends in Neurosciences
Issue number6
StatePublished - 1988
Externally publishedYes


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