Macrophages at the maternal-fetal interface

Michael Z. Zulu; Clive M. Gray; Siamon Gordon; Fernando O. Martinez

doi:10.1016/B978-0-12-821385-8.00006-8

Macrophages at the maternal-fetal interface

Michael Z. Zulu
, Clive M. Gray
, Siamon Gordon
, Fernando O. Martinez

Division of Microbiology and Immunology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Macrophages are myeloid immune cells present in every tissue and specialized in phagocytosis, innate, and adaptive immunity. Macrophages contribute to both homeostasis maintenance and disease, and play an early role in implantation and development, both in the embryo and within the placenta. Macrophages of both maternal and fetal origin, decidual macrophages and Hofbauer cells respectively, contribute to placental functions and defence during gestation and parturition. In this chapter, we discuss the ontogeny of these abundant immune cells in the placenta as well as the evidence for tissue-specific specializations, phenotype and functions in normal pregnancy and in complications.

Original language	English
Title of host publication	Macrophages in the Human Body
Subtitle of host publication	A Tissue Level Approach
Publisher	Elsevier
Pages	265-277
Number of pages	13
ISBN (Electronic)	9780128213858
ISBN (Print)	9780128213865
DOIs	https://doi.org/10.1016/B978-0-12-821385-8.00006-8
State	Published - 01 01 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.

Keywords

Decidua
Macrophages
Maternal-fetal interface
Placenta

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10.1016/B978-0-12-821385-8.00006-8

Cite this

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AU - Zulu, Michael Z.

AU - Gray, Clive M.

AU - Gordon, Siamon

AU - Martinez, Fernando O.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Macrophages are myeloid immune cells present in every tissue and specialized in phagocytosis, innate, and adaptive immunity. Macrophages contribute to both homeostasis maintenance and disease, and play an early role in implantation and development, both in the embryo and within the placenta. Macrophages of both maternal and fetal origin, decidual macrophages and Hofbauer cells respectively, contribute to placental functions and defence during gestation and parturition. In this chapter, we discuss the ontogeny of these abundant immune cells in the placenta as well as the evidence for tissue-specific specializations, phenotype and functions in normal pregnancy and in complications.

AB - Macrophages are myeloid immune cells present in every tissue and specialized in phagocytosis, innate, and adaptive immunity. Macrophages contribute to both homeostasis maintenance and disease, and play an early role in implantation and development, both in the embryo and within the placenta. Macrophages of both maternal and fetal origin, decidual macrophages and Hofbauer cells respectively, contribute to placental functions and defence during gestation and parturition. In this chapter, we discuss the ontogeny of these abundant immune cells in the placenta as well as the evidence for tissue-specific specializations, phenotype and functions in normal pregnancy and in complications.

KW - Decidua

KW - Macrophages

KW - Maternal-fetal interface

KW - Placenta

UR - https://www.scopus.com/pages/publications/85137491181

U2 - 10.1016/B978-0-12-821385-8.00006-8

DO - 10.1016/B978-0-12-821385-8.00006-8

M3 - 章节

AN - SCOPUS:85137491181

SN - 9780128213865

SP - 265

EP - 277

BT - Macrophages in the Human Body

PB - Elsevier

ER -

Macrophages at the maternal-fetal interface

Abstract

Bibliographical note

Keywords

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