Magnetic resonance fat quantification in living donor liver transplantation

H. J. Chiang, L. H. Lin, C. W. Li, C. C. Lin, H. W. Chiang, T. L. Huang, C. L. Chen, Y. F. Cheng*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

25 Scopus citations


Objective Hepatic steatosis can cause substantial problems for both donors and recipients in living donor liver transplantation (LDLT). The aim of this study is to evaluate the accuracy of the magnetic resonance IDEAL (iterative decomposition of water and fat with echo asymmetry and least squares estimation) sequence in quantifying the liver fat during LDLT. Materials and Methods A total of 63 liver donors (29 men and 34 women ranging from 18 to 47 years old with a mean age of 30) who received both magnetic resonance imaging (MRI) and intraoperative liver biopsy were enrolled in this study. MR IDEAL IQ sequences were performed by 1.5-T MRI (Discovery 450; GE Healthcare, Milwaukee, Wis, United States) to estimate the liver fatty content. Accuracy was assessed through linear regression between fat fraction image and pathology grading. Sensitivity and specificity of MR IDEAL IQ fat fractions were also calculated. Results A total of 63 LDLTs were performed and with pathology grading. No fatty content was found in 48 donors (76.2%; group 1), 5% to 10% fatty liver in 11 donors (17.4%; group 2), 11% to 15% fatty liver in 2 donors (3.2%; group 3), and >16% fatty change in 2 donors (3.2%; group 4). MR IDEAL fat fraction results were excellent in prediction of the normal and fatty content and with good correlation with the pathology grading (2.9 ± 0.9, 8.3 ± 4.2, P <.0001). Linear regression between IDEAL image and pathology grading indicated a high accuracy rate (R2 = 0.813, R2 = 0.9286) for all 4 groups. The sensitivity and specificity for detection of liver steatosis in MRI fat fraction image were 100% and 77.1% (P <.0001, 95% confidence interval 0.000-1.000). Conclusion MR IDEAL IQ sequencing is a highly precise and accurate method in quantifying hepatic steatosis for the living donor.

Original languageEnglish
Pages (from-to)666-668
Number of pages3
JournalTransplantation Proceedings
Issue number3
StatePublished - 04 2014


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