Maintenance of CD8 effector T cells by CD4 helper T cells eradicates growing tumors and promotes long-term tumor immunity

Cheng Tao Lin*, Ting Chang Chang, Sheng Wen Shaw, Po Jen Cheng, Ching Tai Huang, Angel Chao, Yung Kuei Soong, Chyong Huey Lai

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

23 Scopus citations

Abstract

Human papillomavirus, particularly type 16 (HPV-16), is present in more than 99% of cervical cancers, and oncogenic HPV infection is one of the most important etiologies. It is now clear that CD4+ T cells play an important role in controlling HPV-associated lesions because immunocompromised patients have a higher frequency of HPV-associated lesions. In the current study, we characterized the significance of CD4+ T cells in the generation of E7-specific CD8+ T cell immune responses in mice vaccinated with SINrep5-E7/HSP70 and boosted with vac-E7/HSP70. In addition, we characterized the contribution of CD4+ T cells to the long-term antitumor effects. We found that vaccination with CD4 depletion significantly reduced the number of E7-specific CD8+ T cells in mice. Furthermore, CD4+ T cells are important for the long-term anti-tumor effects generated by vaccination with SINrep5-E7/HSP70 and booster with vac-E7/HSP70. Thus, CD4 T cells clearly have an important role in successful tumor immunity and maintenance of long-term tumor antigen-specific memory responses in vaccinated mice with established tumors.

Original languageEnglish
Pages (from-to)6199-6207
Number of pages9
JournalVaccine
Volume24
Issue number37-39
DOIs
StatePublished - 11 09 2006
Externally publishedYes

Keywords

  • Cytotoxic T cells
  • Human papillomavirus
  • Immunotherapy

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