TY - JOUR
T1 - Major hematological diseases associated with cleft lip and palate
AU - Lin, C. H.
AU - Lo, L. J.
AU - Wang, M. L.
AU - Chen, Y. R.
AU - Noordhoff, M. S.
PY - 2000
Y1 - 2000
N2 - Objective: Cleft lip and palate is among the most common congenital anomalies. Its association with major blood disorders has rarely been reported. The purpose of this study was to report two patients who had major blood diseases associated with cleft lip and palate. Patients and Results: From June 1995 to December 1997, there were 2700 patients with cleft lip, cleft palate, or both who received treatment at Chang Gung Memorial Hospital. Two of them were found to have major hematological disorders. In both cases, the disorder was detected by preoperative blood cell counts and white cell differentiation. Case 1 was a 21-year-old woman patient with repaired right cleft lip. She was admitted for alveolar bone grafting and closure of oronasal fistula. Abnormal presentation of blast cells was found, and subsequent bone marrow study confirmed acute lymphocytic leukemia. Case 2 was a 26-year-old man with left secondary cleft lip nasal deformity scheduled to receive staged reconstructive operations. An elevated platelet count was found and subsequently confirmed to represent essential thrombocytosis. In both cases, reconstructive operations for the cleft-related deformities were performed. Conclusions: Association of major hemotological disorders and cleft lip, palate, or both is rare and is reported herein.
AB - Objective: Cleft lip and palate is among the most common congenital anomalies. Its association with major blood disorders has rarely been reported. The purpose of this study was to report two patients who had major blood diseases associated with cleft lip and palate. Patients and Results: From June 1995 to December 1997, there were 2700 patients with cleft lip, cleft palate, or both who received treatment at Chang Gung Memorial Hospital. Two of them were found to have major hematological disorders. In both cases, the disorder was detected by preoperative blood cell counts and white cell differentiation. Case 1 was a 21-year-old woman patient with repaired right cleft lip. She was admitted for alveolar bone grafting and closure of oronasal fistula. Abnormal presentation of blast cells was found, and subsequent bone marrow study confirmed acute lymphocytic leukemia. Case 2 was a 26-year-old man with left secondary cleft lip nasal deformity scheduled to receive staged reconstructive operations. An elevated platelet count was found and subsequently confirmed to represent essential thrombocytosis. In both cases, reconstructive operations for the cleft-related deformities were performed. Conclusions: Association of major hemotological disorders and cleft lip, palate, or both is rare and is reported herein.
KW - Cleft lip and palate
KW - Hematological disease
UR - http://www.scopus.com/inward/record.url?scp=0033781985&partnerID=8YFLogxK
U2 - 10.1597/1545-1569(2000)037<0512:MHDAWC>2.0.CO;2
DO - 10.1597/1545-1569(2000)037<0512:MHDAWC>2.0.CO;2
M3 - 文章
C2 - 11034036
AN - SCOPUS:0033781985
SN - 1545-1569
VL - 37
SP - 512
EP - 515
JO - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
JF - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
IS - 5
ER -