Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma

Hsuan Jen Shih; Ming Chung Kuo; Tung Liang Lin; Hsiao Wen Kao; Jin Hou Wu; Yu Shin Hung; Che Wei Ou; Yi Jiun Su; Hung Chang

doi:10.3892/ol.2023.14190

Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma

Hsuan Jen Shih
, Ming Chung Kuo
, Tung Liang Lin
, Hsiao Wen Kao
, Jin Hou Wu
, Yu Shin Hung
, Che Wei Ou
, Yi Jiun Su
, Hung Chang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

The effective prognostic factors for primary mediastinal large B-cell lymphoma (PMLBCL) vary among published studies. The aim of the present study was to explore the factors influencing the overall survival (OS) and progression-free survival (PFS) of patients with PMLBCL at a single institute in Taiwan. This retrospective study was conducted to analyze the prognostic impact of age, sex, disease stage, International Prognostic Index (IPI) score, treatment modality and initial response. A total of 72 patients with a median age of 28 years were included in the study. The mean OS and PFS were 171.40 and 159.77 months, respectively. Female sex, age ≤60 years, receiving radiotherapy (RT) and achieving a complete response were found to be associated with a significantly improved OS and PFS.

Original language	English
Article number	57
Journal	Oncology Letters
Volume	27
Issue number	2
DOIs	https://doi.org/10.3892/ol.2023.14190
State	Published - 02 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2024 The Author(s).

Keywords

age
primary mediastinal large B cell lymphoma
prognosis
sex

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3892/ol.2023.14190

Cite this

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title = "Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma",

abstract = "The effective prognostic factors for primary mediastinal large B-cell lymphoma (PMLBCL) vary among published studies. The aim of the present study was to explore the factors influencing the overall survival (OS) and progression-free survival (PFS) of patients with PMLBCL at a single institute in Taiwan. This retrospective study was conducted to analyze the prognostic impact of age, sex, disease stage, International Prognostic Index (IPI) score, treatment modality and initial response. A total of 72 patients with a median age of 28 years were included in the study. The mean OS and PFS were 171.40 and 159.77 months, respectively. Female sex, age ≤60 years, receiving radiotherapy (RT) and achieving a complete response were found to be associated with a significantly improved OS and PFS.",

keywords = "age, primary mediastinal large B cell lymphoma, prognosis, sex",

author = "Shih, \{Hsuan Jen\} and Kuo, \{Ming Chung\} and Lin, \{Tung Liang\} and Kao, \{Hsiao Wen\} and Wu, \{Jin Hou\} and Hung, \{Yu Shin\} and Ou, \{Che Wei\} and Su, \{Yi Jiun\} and Hung Chang",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s).",

year = "2024",

month = feb,

doi = "10.3892/ol.2023.14190",

language = "英语",

volume = "27",

journal = "Oncology Letters",

issn = "1792-1074",

publisher = "Spandidos Publications",

number = "2",

}

TY - JOUR

T1 - Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma

AU - Shih, Hsuan Jen

AU - Kuo, Ming Chung

AU - Lin, Tung Liang

AU - Kao, Hsiao Wen

AU - Wu, Jin Hou

AU - Hung, Yu Shin

AU - Ou, Che Wei

AU - Su, Yi Jiun

AU - Chang, Hung

PY - 2024/2

Y1 - 2024/2

N2 - The effective prognostic factors for primary mediastinal large B-cell lymphoma (PMLBCL) vary among published studies. The aim of the present study was to explore the factors influencing the overall survival (OS) and progression-free survival (PFS) of patients with PMLBCL at a single institute in Taiwan. This retrospective study was conducted to analyze the prognostic impact of age, sex, disease stage, International Prognostic Index (IPI) score, treatment modality and initial response. A total of 72 patients with a median age of 28 years were included in the study. The mean OS and PFS were 171.40 and 159.77 months, respectively. Female sex, age ≤60 years, receiving radiotherapy (RT) and achieving a complete response were found to be associated with a significantly improved OS and PFS.

AB - The effective prognostic factors for primary mediastinal large B-cell lymphoma (PMLBCL) vary among published studies. The aim of the present study was to explore the factors influencing the overall survival (OS) and progression-free survival (PFS) of patients with PMLBCL at a single institute in Taiwan. This retrospective study was conducted to analyze the prognostic impact of age, sex, disease stage, International Prognostic Index (IPI) score, treatment modality and initial response. A total of 72 patients with a median age of 28 years were included in the study. The mean OS and PFS were 171.40 and 159.77 months, respectively. Female sex, age ≤60 years, receiving radiotherapy (RT) and achieving a complete response were found to be associated with a significantly improved OS and PFS.

KW - age

KW - primary mediastinal large B cell lymphoma

KW - prognosis

KW - sex

UR - https://www.scopus.com/pages/publications/85180592766

U2 - 10.3892/ol.2023.14190

DO - 10.3892/ol.2023.14190

M3 - 文章

AN - SCOPUS:85180592766

SN - 1792-1074

VL - 27

JO - Oncology Letters

JF - Oncology Letters

IS - 2

M1 - 57

ER -

Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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