Mammalian RNA virus-derived small RNA: Biogenesis and functional activity

Kuo Feng Weng; Po Ting Hsieh; Hsing I. Huang; Shin Ru Shih

doi:10.1016/j.micinf.2015.04.005

Mammalian RNA virus-derived small RNA: Biogenesis and functional activity

Kuo Feng Weng^*, Po Ting Hsieh, Hsing I. Huang, Shin Ru Shih

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The role of virus-derived small RNAs (vsRNAs) has been identified as an antiviral mechanism in plants, arthropods, and nematodes. Although mammalian DNA viruses have been observed to encode functional miRNAs, whether RNA virus infection generates functional vsRNAs remains under discussion. This article reviews the most recent reports regarding pathways for generating vsRNAs and the identified vsRNA activity in mammalian cells infected with RNA viruses. We also discuss several hypotheses regarding the roles of mammalian vsRNAs and comment on the potential directions for this research field.

Original language	English
Pages (from-to)	557-563
Number of pages	7
Journal	Microbes and Infection
Volume	17
Issue number	8
DOIs	https://doi.org/10.1016/j.micinf.2015.04.005
State	Published - 2015

Bibliographical note

Publisher Copyright:
© 2015 Institut Pasteur.

Keywords

Mammalian
RNA virus
RNAi
SiRNA
Small RNA
vsRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.micinf.2015.04.005

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title = "Mammalian RNA virus-derived small RNA: Biogenesis and functional activity",

abstract = "The role of virus-derived small RNAs (vsRNAs) has been identified as an antiviral mechanism in plants, arthropods, and nematodes. Although mammalian DNA viruses have been observed to encode functional miRNAs, whether RNA virus infection generates functional vsRNAs remains under discussion. This article reviews the most recent reports regarding pathways for generating vsRNAs and the identified vsRNA activity in mammalian cells infected with RNA viruses. We also discuss several hypotheses regarding the roles of mammalian vsRNAs and comment on the potential directions for this research field.",

keywords = "Mammalian, RNA virus, RNAi, SiRNA, Small RNA, vsRNA",

author = "Weng, {Kuo Feng} and Hsieh, {Po Ting} and Huang, {Hsing I.} and Shih, {Shin Ru}",

note = "Publisher Copyright: {\textcopyright} 2015 Institut Pasteur.",

year = "2015",

doi = "10.1016/j.micinf.2015.04.005",

language = "英语",

volume = "17",

pages = "557--563",

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TY - JOUR

T1 - Mammalian RNA virus-derived small RNA

T2 - Biogenesis and functional activity

AU - Weng, Kuo Feng

AU - Hsieh, Po Ting

AU - Huang, Hsing I.

AU - Shih, Shin Ru

PY - 2015

Y1 - 2015

N2 - The role of virus-derived small RNAs (vsRNAs) has been identified as an antiviral mechanism in plants, arthropods, and nematodes. Although mammalian DNA viruses have been observed to encode functional miRNAs, whether RNA virus infection generates functional vsRNAs remains under discussion. This article reviews the most recent reports regarding pathways for generating vsRNAs and the identified vsRNA activity in mammalian cells infected with RNA viruses. We also discuss several hypotheses regarding the roles of mammalian vsRNAs and comment on the potential directions for this research field.

AB - The role of virus-derived small RNAs (vsRNAs) has been identified as an antiviral mechanism in plants, arthropods, and nematodes. Although mammalian DNA viruses have been observed to encode functional miRNAs, whether RNA virus infection generates functional vsRNAs remains under discussion. This article reviews the most recent reports regarding pathways for generating vsRNAs and the identified vsRNA activity in mammalian cells infected with RNA viruses. We also discuss several hypotheses regarding the roles of mammalian vsRNAs and comment on the potential directions for this research field.

KW - Mammalian

KW - RNA virus

KW - RNAi

KW - SiRNA

KW - Small RNA

KW - vsRNA

UR - http://www.scopus.com/inward/record.url?scp=84942836347&partnerID=8YFLogxK

U2 - 10.1016/j.micinf.2015.04.005

DO - 10.1016/j.micinf.2015.04.005

M3 - 文献综述

C2 - 25980760

AN - SCOPUS:84942836347

SN - 1286-4579

VL - 17

SP - 557

EP - 563

JO - Microbes and Infection

JF - Microbes and Infection

IS - 8

ER -

Mammalian RNA virus-derived small RNA: Biogenesis and functional activity

Abstract

Bibliographical note

Keywords

UN SDGs

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