Mantle cell lymphoma with diffuse gastrointestinal tract involvement: A case report

Ming Tzung Lin, Yuan Hung Kuo, Seng Kee Chuah, Yi Chun Chiu, Chao Cheng Huang, Wei Chen Tai, Chien Hung Chen*, Chuan Mo Lee

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations


Gastrointestinal tract mantle cell lymphoma accounts for only approximately 1% to 2% of non-Hodgkin lymphomas. Multiple lymphomatous polyposis is an uncommon disease entity that is regarded as the intestinal form of mantle cell lymphoma. We present here a case of mantle cell lymphoma with peculiar endoscopic presentations in the stomach and colon in a 70 year-old woman. She suffered from abdominal pain, progressive abdominal fullness, and body weight loss of 11 kilograms within 6 months. Big polypoid masses with ulcerations were found at the fundus and high body of the stomach by endoscopy and at the cecal area by colonoscopy. Biopsies from both sites confirmed the diagnosis of mantle cell lymphoma. Computer tomography of the abdomen revealed diffuse wall thickening involving the gastric fundus, high body, antrum, duodenum and proximal ascending colon with extensive mesentery lymph node enlargement. She received one cycle of cyclophosphamide, vincristine and prednisone(COP) followed by seven cycles of rituximab plus cyclophosphamide and prednisone, which resulted in significant tumor regression and prompt symptomatic palliation.

Original languageEnglish
Pages (from-to)555-560
Number of pages6
JournalJournal of Internal Medicine of Taiwan
Issue number6
StatePublished - 12 2009


  • Mantle cell lymphoma
  • Multiple lymphomatous polyposis
  • Non-Hodgkin lymphomas
  • Rare endoscopic presentations


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