Mapping signals that are important for nuclear and nucleolar localization in MCRS2

Chung Wen Kuo; Wen Hung Wang; Shih Tung Liu

doi:10.1007/s10059-011-1033-3

Mapping signals that are important for nuclear and nucleolar localization in MCRS2

Chung Wen Kuo, Wen Hung Wang, Shih Tung Liu^*

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

MCRS2 is an oncoprotein that is sequestered in the nucleolus. When in the nucleolus, it promotes the transcription of the rRNA gene. MCRS2 also brings proteins into the nucleolus to change their function. This study analyzes the sequence of MCRS2 and determines that the nuclear localization signal, which has the sequence KRKK, is situated between amino acids 66 and 69. Meanwhile, MCRS2 contains a bipartite nucleolar localization signal, which comprises a KKSK motif, located between amino acids 133 and 136, and a downstream 152-amino acid region, from amino acid 314 to 465. The results of this study are important to understand the function of MCRS2.

Original language	English
Pages (from-to)	547-552
Number of pages	6
Journal	Molecules and Cells
Volume	31
Issue number	6
DOIs	https://doi.org/10.1007/s10059-011-1033-3
State	Published - 06 2011
Externally published	Yes

Keywords

MCRS2
nucleolar localization
nucleolus

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10.1007/s10059-011-1033-3

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title = "Mapping signals that are important for nuclear and nucleolar localization in MCRS2",

abstract = "MCRS2 is an oncoprotein that is sequestered in the nucleolus. When in the nucleolus, it promotes the transcription of the rRNA gene. MCRS2 also brings proteins into the nucleolus to change their function. This study analyzes the sequence of MCRS2 and determines that the nuclear localization signal, which has the sequence KRKK, is situated between amino acids 66 and 69. Meanwhile, MCRS2 contains a bipartite nucleolar localization signal, which comprises a KKSK motif, located between amino acids 133 and 136, and a downstream 152-amino acid region, from amino acid 314 to 465. The results of this study are important to understand the function of MCRS2.",

keywords = "MCRS2, nucleolar localization, nucleolus",

author = "Kuo, {Chung Wen} and Wang, {Wen Hung} and Liu, {Shih Tung}",

year = "2011",

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T1 - Mapping signals that are important for nuclear and nucleolar localization in MCRS2

AU - Kuo, Chung Wen

AU - Wang, Wen Hung

AU - Liu, Shih Tung

PY - 2011/6

Y1 - 2011/6

N2 - MCRS2 is an oncoprotein that is sequestered in the nucleolus. When in the nucleolus, it promotes the transcription of the rRNA gene. MCRS2 also brings proteins into the nucleolus to change their function. This study analyzes the sequence of MCRS2 and determines that the nuclear localization signal, which has the sequence KRKK, is situated between amino acids 66 and 69. Meanwhile, MCRS2 contains a bipartite nucleolar localization signal, which comprises a KKSK motif, located between amino acids 133 and 136, and a downstream 152-amino acid region, from amino acid 314 to 465. The results of this study are important to understand the function of MCRS2.

AB - MCRS2 is an oncoprotein that is sequestered in the nucleolus. When in the nucleolus, it promotes the transcription of the rRNA gene. MCRS2 also brings proteins into the nucleolus to change their function. This study analyzes the sequence of MCRS2 and determines that the nuclear localization signal, which has the sequence KRKK, is situated between amino acids 66 and 69. Meanwhile, MCRS2 contains a bipartite nucleolar localization signal, which comprises a KKSK motif, located between amino acids 133 and 136, and a downstream 152-amino acid region, from amino acid 314 to 465. The results of this study are important to understand the function of MCRS2.

KW - MCRS2

KW - nucleolar localization

KW - nucleolus

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DO - 10.1007/s10059-011-1033-3

M3 - 文章

C2 - 21533551

AN - SCOPUS:79960596498

SN - 1016-8478

VL - 31

SP - 547

EP - 552

JO - Molecules and Cells

JF - Molecules and Cells

IS - 6

ER -

Mapping signals that are important for nuclear and nucleolar localization in MCRS2

Abstract

Keywords

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