Maternal and neonatal outcomes of respiratory failure during pregnancy

Chen Yiu Hung, Han Chung Hu, Li Chung Chiu, Chih Hao Chang, Li Fu Li, Chung Chi Huang, Chuan Chi Kao, Po Jen Cheng, Kuo Chin Kao*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

16 Scopus citations

Abstract

Background: Obstetric patients comprise a limited portion of intensive care unit patients, but they often present with unfamiliar conditions and exhibit the potential for catastrophic deterioration. This study evaluated the maternal and neonatal outcomes of respiratory failure during pregnancy. Methods: Information on 71 patients at >25 weeks gestation in the ICU with respiratory failure was recorded between 2009 and 2013. The characteristics and outcomes of mothers and fetuses were determined through a retrospective chart review and evaluated using Student's t test, chi-square test, and Fisher's exact test. Results: The leading causes of respiratory failure were postpartum hemorrhage and severe preeclampsia in the obstetric causes group and pneumonia in the nonobstetric causes group during pregnancy and the peripartum period. The non-obstetric causes group exhibited a higher incidence of acute respiratory distress syndrome and renal replacement therapy as well as requiring more ventilator days. The patients in the obstetric causes group showed significant improvement after delivery in the partial pressure of arterial oxygen to the fraction of inspired oxygen and peak inspiratory pressure decrease. Both groups exhibited high incidences of neonatal respiratory distress syndrome. Neonatal complications resulting from meconium aspiration syndrome (MAS) and sepsis were more common in the non-obstetric causes group; however, neurological development impairment was more common in the obstetric causes group. Conclusion: Obstetric cause was associated with longer ventilator free days and fewer episodes of ARDS after delivery. Neonatal complications resulting from different etiologies of respiratory failure were found to differ.

Original languageEnglish
Pages (from-to)413-420
Number of pages8
JournalJournal of the Formosan Medical Association
Volume117
Issue number5
DOIs
StatePublished - 05 2018

Bibliographical note

Publisher Copyright:
© 2017

Keywords

  • Acute respiratory distress syndrome
  • Neonatal
  • Obstetric
  • Outcome
  • Respiratory failure

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