Maternal High-Fat Diet and Offspring Hypertension

You Lin Tain, Chien Ning Hsu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


The incidence of hypertension has increased to epidemic levels in the past decades. Increasing evidence reveals that maternal dietary habits play a crucial role in the development of hypertension in adult offspring. In humans, increased fat consumption has been considered responsible for obesity and associated diseases. Maternal diets rich in saturated fats have been widely employed in animal models to study various adverse offspring outcomes. In this review, we discussed current evidence linking maternal high-fat diet to offspring hypertension. We also provided an in-depth overview of the potential mechanisms underlying hypertension of developmental origins that are programmed by maternal high-fat intake from animal studies. Furthermore, this review also presented an overview of how reprogramming interventions can prevent maternal high-fat-diet-induced hypertension in adult offspring. Overall, recent advances in understanding mechanisms behind programming and reprogramming of maternal high-fat diet on hypertension of developmental origins might provide the answers to curtail this epidemic. Still, more research is needed to translate research findings into practice.

Original languageEnglish
Article number8179
JournalInternational Journal of Molecular Sciences
Issue number15
StatePublished - 08 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.


  • developmental origins of health and disease (DOHaD)
  • epigenetic regulation
  • gut microbiota
  • high-fat diet
  • hypertension
  • nitric oxide
  • oxidative stress
  • renin-angiotensin system


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