Maternal resveratrol treatment re-programs and maternal high-fat diet-induced retroperitoneal adiposity in male offspring

Ti An Tsai, Chang Ku Tsai, Li Tung Huang, Jiunn Ming Sheen, Mao Meng Tiao, You Lin Tain, Chih Cheng Chen, I. Chun Lin, Yun Ju Lai, Ching Chou Tsai, Yu Ju Lin, Hong Ren Yu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

19 Scopus citations


Obesity during pregnancy increases the risk of cardiovascular problems, diabetes, asthma, and cognitive impairments, affecting the offspring. It is important to reduce the negative effects of obesity and high-fat (HF) diet during pregnancy. We employed a rat model of maternal HF diet to evaluate the possible de-programming effects of resveratrol in rodent male offspring with maternal HF diet/obesity. Male rat offspring were randomized into four groups: maternal control diet/postnatal control diet, maternal HF diet/postnatal control diet, maternal control diet plus maternal resveratrol treatment/postnatal control diet, and maternal HF diet plus maternal resveratrol treatment/postnatal control diet. Maternal HF diet during pregnancy plus lactation resulted in retroperitoneal adiposity in the male offspring. Maternal resveratrol treatment re-programmed maternal HF exposure-induced visceral adiposity. Offspring that received prenatal HF diet showed higher leptin/soluble leptin receptor (sOB-R) ratio than offspring that received prenatal control diet. Maternal resveratrol treatment ameliorated maternal HF exposure-induced increase in leptin/sOB-R ratio and altered the expression of genes for crucial fatty acid synthesis enzymes in the offspring. Thus, maternal resveratrol administration reduces retroperitoneal adiposity in rat offspring exposed to prenatal HF diet/obesity and could be used to ameliorate negative effects of maternal HF diet in the offspring.

Original languageEnglish
Article number2780
JournalInternational Journal of Environmental Research and Public Health
Issue number8
StatePublished - 02 04 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Adipose tissue
  • High-fat diet
  • Leptin
  • Prenatal
  • Resveratrol


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