Abstract
Background: Matrix-assisted laser desorption ionization/time-of-flight (MALDI-TOF) mass spectrometry is known as an extremely sensitive analytical tool for characterizing different types of biological compounds including proteins, peptides and lipids. Since MALDI-TOF analysis requires very simple sample pretreatment, the technique can be used for rapidly detecting biochemical compounds serving as disease biomarkers. Results: This mini-review focuses on the applications of MALDI-TOF in the detection of potential disease biomarkers in various biological samples. Conclusions: The potential disease biomarkers are mostly abundant proteins, peptides, or lipids including: albumin; hemoglobin; α-defensins; trimethylamine; phospholipids; and glycatedα- and β-globin, which are indicators of albuminuria; fecal occult blood and ischemic stroke; dry eye disease and/or aging; trimethylaniuria; breast cancer; and diabetes, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 266-275 |
| Number of pages | 10 |
| Journal | Clinica Chimica Acta |
| Volume | 415 |
| DOIs | |
| State | Published - 16 01 2013 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Clinical diagnosis
- Disease biomarkers
- Matrix-assisted laser desorption ionization/time-of-flight mass spectrometry
- Multivariate analysis
- Principle component analysis
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