Matrix metalloproteinase-1 polymorphism in Taiwanese patients with endobronchial tuberculosis

Han Pin Kuo; Yu Min Wang; Chun Hua Wang; Chih Chen He; Shu Min Lin; Horng Chyuan Lin; Chien Ying Liu; Kuo Hsiung Huang; Ling Ling Hsieh; Chien Da Huang

doi:10.1016/j.tube.2007.08.010

Matrix metalloproteinase-1 polymorphism in Taiwanese patients with endobronchial tuberculosis

Han Pin Kuo, Yu Min Wang, Chun Hua Wang, Chih Chen He, Shu Min Lin, Horng Chyuan Lin, Chien Ying Liu, Kuo Hsiung Huang, Ling Ling Hsieh, Chien Da Huang^*

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

24 Scopus citations

Abstract

Endobronchial tuberculosis (TB) often leads to some degree of tracheobronchial stenosis. Because matrix metalloproteinases (MMPs) play an essential role in tissue remodeling in the airways, we investigated the role of MMP-1 polymorphism in patients with endobronchial TB. One hundred and one cases of pulmonary TB in Taiwanese patients were genotyped for the 1G/2G polymorphism of MMP-1 promoter (-1607 bp). Bronchoscopic examination was performed to determine the presence of endobronchial involvement. Levels of MMP-1 in peripheral blood monocytes and in bronchial biopsies were also determined. 1G genotypes of MMP-1 polymorphism, containing at least one 1G allele, were associated with the presence of endobronchial TB. Using multivariate analysis, 1G genotypes and female gender were independent predictors of the development of endobronchial TB. Endobronchial TB patients with 1G genotypes had a 9.86-fold greater risk of developing tracheobronchial stenosis. IL-1β increased levels of MMP-1 in peripheral blood monocytes of TB patients with 1G genotypes. MMP-1 activity was also present in the endobronchial TB granuloma from patients with 1G/1G genotype. 1G genotypes of MMP-1 polymorphism were associated with a greater risk of developing tracheobronchial stenosis through up-regulation of MMP-1 activity.

Original language	English
Pages (from-to)	262-267
Number of pages	6
Journal	Tuberculosis
Volume	88
Issue number	3
DOIs	https://doi.org/10.1016/j.tube.2007.08.010
State	Published - 05 2008

Keywords

Endobronchial tuberculosis
Matrix metalloproteinase-1
Polymorphism
Stenosis
Taiwanese

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tube.2007.08.010

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title = "Matrix metalloproteinase-1 polymorphism in Taiwanese patients with endobronchial tuberculosis",

abstract = "Endobronchial tuberculosis (TB) often leads to some degree of tracheobronchial stenosis. Because matrix metalloproteinases (MMPs) play an essential role in tissue remodeling in the airways, we investigated the role of MMP-1 polymorphism in patients with endobronchial TB. One hundred and one cases of pulmonary TB in Taiwanese patients were genotyped for the 1G/2G polymorphism of MMP-1 promoter (-1607 bp). Bronchoscopic examination was performed to determine the presence of endobronchial involvement. Levels of MMP-1 in peripheral blood monocytes and in bronchial biopsies were also determined. 1G genotypes of MMP-1 polymorphism, containing at least one 1G allele, were associated with the presence of endobronchial TB. Using multivariate analysis, 1G genotypes and female gender were independent predictors of the development of endobronchial TB. Endobronchial TB patients with 1G genotypes had a 9.86-fold greater risk of developing tracheobronchial stenosis. IL-1β increased levels of MMP-1 in peripheral blood monocytes of TB patients with 1G genotypes. MMP-1 activity was also present in the endobronchial TB granuloma from patients with 1G/1G genotype. 1G genotypes of MMP-1 polymorphism were associated with a greater risk of developing tracheobronchial stenosis through up-regulation of MMP-1 activity.",

keywords = "Endobronchial tuberculosis, Matrix metalloproteinase-1, Polymorphism, Stenosis, Taiwanese",

author = "Kuo, {Han Pin} and Wang, {Yu Min} and Wang, {Chun Hua} and He, {Chih Chen} and Lin, {Shu Min} and Lin, {Horng Chyuan} and Liu, {Chien Ying} and Huang, {Kuo Hsiung} and Hsieh, {Ling Ling} and Huang, {Chien Da}",

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AU - Kuo, Han Pin

AU - Wang, Yu Min

AU - Wang, Chun Hua

AU - He, Chih Chen

AU - Lin, Shu Min

AU - Lin, Horng Chyuan

AU - Liu, Chien Ying

AU - Huang, Kuo Hsiung

AU - Hsieh, Ling Ling

AU - Huang, Chien Da

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N2 - Endobronchial tuberculosis (TB) often leads to some degree of tracheobronchial stenosis. Because matrix metalloproteinases (MMPs) play an essential role in tissue remodeling in the airways, we investigated the role of MMP-1 polymorphism in patients with endobronchial TB. One hundred and one cases of pulmonary TB in Taiwanese patients were genotyped for the 1G/2G polymorphism of MMP-1 promoter (-1607 bp). Bronchoscopic examination was performed to determine the presence of endobronchial involvement. Levels of MMP-1 in peripheral blood monocytes and in bronchial biopsies were also determined. 1G genotypes of MMP-1 polymorphism, containing at least one 1G allele, were associated with the presence of endobronchial TB. Using multivariate analysis, 1G genotypes and female gender were independent predictors of the development of endobronchial TB. Endobronchial TB patients with 1G genotypes had a 9.86-fold greater risk of developing tracheobronchial stenosis. IL-1β increased levels of MMP-1 in peripheral blood monocytes of TB patients with 1G genotypes. MMP-1 activity was also present in the endobronchial TB granuloma from patients with 1G/1G genotype. 1G genotypes of MMP-1 polymorphism were associated with a greater risk of developing tracheobronchial stenosis through up-regulation of MMP-1 activity.

AB - Endobronchial tuberculosis (TB) often leads to some degree of tracheobronchial stenosis. Because matrix metalloproteinases (MMPs) play an essential role in tissue remodeling in the airways, we investigated the role of MMP-1 polymorphism in patients with endobronchial TB. One hundred and one cases of pulmonary TB in Taiwanese patients were genotyped for the 1G/2G polymorphism of MMP-1 promoter (-1607 bp). Bronchoscopic examination was performed to determine the presence of endobronchial involvement. Levels of MMP-1 in peripheral blood monocytes and in bronchial biopsies were also determined. 1G genotypes of MMP-1 polymorphism, containing at least one 1G allele, were associated with the presence of endobronchial TB. Using multivariate analysis, 1G genotypes and female gender were independent predictors of the development of endobronchial TB. Endobronchial TB patients with 1G genotypes had a 9.86-fold greater risk of developing tracheobronchial stenosis. IL-1β increased levels of MMP-1 in peripheral blood monocytes of TB patients with 1G genotypes. MMP-1 activity was also present in the endobronchial TB granuloma from patients with 1G/1G genotype. 1G genotypes of MMP-1 polymorphism were associated with a greater risk of developing tracheobronchial stenosis through up-regulation of MMP-1 activity.

KW - Endobronchial tuberculosis

KW - Matrix metalloproteinase-1

KW - Polymorphism

KW - Stenosis

KW - Taiwanese

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JO - Tuberculosis

JF - Tuberculosis

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ER -

Matrix metalloproteinase-1 polymorphism in Taiwanese patients with endobronchial tuberculosis

Abstract

Keywords

UN SDGs

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