Abstract
In this work, the solubility of ergosterol, which is a natural phytosterol exhibiting cholesterol-lowering properties and is of particular interest to the food and nutraceutical industries, in supercritical carbon dioxide was measured with a semi-flow type phase equilibrium apparatus. The solubility experiment was performed at pressures in the range of 120-240bar and at temperatures of 318.15, 323.15, and 333.15K, and the measured solubility ranged from 2.9×10-6 to 3.0×10-5. The high-pressure solubility data for each isotherm were correlated by the Schmitt-Reid and Giddings models with average absolute relative deviations (AARD) ranging from 4.1 to 9.7% and 2.2 to 5.5%, respectively. The Chrastil model and the Méndez-Santiago and Teja model were also used to fit the entire data set yielding AARDs of 7.6% and 8.5%, respectively. Furthermore, the Peng-Robinson equation of state (EOS) using one-parameter and two-parameter van der Waals mixing rules was employed to fit the experimental solubility data with the latter giving a significantly smaller AARD of 6.4%. Retrograde behavior of the solute's solubility in the supercritical fluid was observed and was also predicted by the equation of state.
| Original language | English |
|---|---|
| Pages (from-to) | 19-26 |
| Number of pages | 8 |
| Journal | Journal of the Taiwan Institute of Chemical Engineers |
| Volume | 44 |
| Issue number | 1 |
| DOIs | |
| State | Published - 01 2013 |
| Externally published | Yes |
Keywords
- Carbon dioxide
- Ergosterol
- Modeling
- Solubility
- Supercritical fluid