Mechanical tensile strain stimulation of chondrocytes and meniscus cells in thermo-responsive hydrogel

Jyh Ping Chen*, Tai Hong Cheng

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Temperature-responsive hydrogel scaffold containing chitosan and hyaluronic acid was used to entrap primary chondrocytes and meniscus cells. The effect of dynamic tensile strain on the cells/hydrogel constructs was evaluated by measuring cell proliferation, biosynthetic activity, and viability. The results demonstrated that mechanical deformation resulted in substantial increase in glycosaminoglycan and collagen productions over static controls while not significantly affecting cell proliferation and viability.

Original languageEnglish
Title of host publicationISOB 2011 - Proceedings of the 1st International Symposium on Bioengineering
Pages306-313
Number of pages8
DOIs
StatePublished - 2011
Externally publishedYes
Event1st International Symposium on Bioengineering, ISOB 2011 - Singapore, Singapore
Duration: 19 01 201119 01 2011

Publication series

NameISOB 2011 - Proceedings of the 1st International Symposium ISOB 2011 - Proceedings of the 1st International Symposium on Bioengineering

Conference

Conference1st International Symposium on Bioengineering, ISOB 2011
Country/TerritorySingapore
CitySingapore
Period19/01/1119/01/11

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