Abstract
An unusual case of medullary carcinoma of the thyroid gland with melanin production is described. In addition to typical histologic characteristics, some tumor cells show strong positive reaction for calcitonin by immunohistochemical study. Ultrastructurally dense-core granules and immature melanosomes are found in the same tumor cell. The tumor is thought to arise from a common precursor cell of neural crest origin with both C cell and melanocytic differentiation capable of producing both calcitonin and melanin.
| Original language | English |
|---|---|
| Pages (from-to) | 377-380 |
| Number of pages | 4 |
| Journal | Archives of Pathology and Laboratory Medicine |
| Volume | 113 |
| Issue number | 4 |
| State | Published - 1989 |
| Externally published | Yes |
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SDG 3 Good Health and Well-being
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