Melatonin and Kidney Health: From Fetal Stage to Later Life

Kuo Shu Tang; Chun Yi Ho; Chien Ning Hsu; You Lin Tain

doi:10.3390/ijms24098105

Melatonin and Kidney Health: From Fetal Stage to Later Life

Kuo Shu Tang, Chun Yi Ho, Chien Ning Hsu^*, You Lin Tain^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin’s effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring’s kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.

Original language	English
Article number	8105
Journal	International Journal of Molecular Sciences
Volume	24
Issue number	9
DOIs	https://doi.org/10.3390/ijms24098105
State	Published - 30 04 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

antioxidant
circadian rhythm
developmental origin of health and disease (DOHaD)
developmental programming
kidney disease
melatonin
pregnancy
Pineal Gland
Renal Insufficiency, Chronic/drug therapy
Circadian Rhythm
Kidney
Animals
Models, Animal
Melatonin/pharmacology

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title = "Melatonin and Kidney Health: From Fetal Stage to Later Life",

abstract = "Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin{\textquoteright}s effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring{\textquoteright}s kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.",

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author = "Tang, {Kuo Shu} and Ho, {Chun Yi} and Hsu, {Chien Ning} and Tain, {You Lin}",

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doi = "10.3390/ijms24098105",

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AU - Ho, Chun Yi

AU - Hsu, Chien Ning

AU - Tain, You Lin

PY - 2023/4/30

Y1 - 2023/4/30

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KW - antioxidant

KW - circadian rhythm

KW - developmental origin of health and disease (DOHaD)

KW - developmental programming

KW - kidney disease

KW - melatonin

KW - pregnancy

KW - Pineal Gland

KW - Renal Insufficiency, Chronic/drug therapy

KW - Circadian Rhythm

KW - Kidney

KW - Animals

KW - Models, Animal

KW - Melatonin/pharmacology

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ER -

Melatonin and Kidney Health: From Fetal Stage to Later Life

Abstract

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Keywords

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