Melatonin and Kidney Health: From Fetal Stage to Later Life

Kuo Shu Tang; Chun Yi Ho; Chien Ning Hsu; You Lin Tain

doi:10.3390/ijms24098105

Melatonin and Kidney Health: From Fetal Stage to Later Life

Kuo Shu Tang
, Chun Yi Ho
, Chien Ning Hsu^*
, You Lin Tain^*

^*Corresponding author for this work

School of Medicine

Chang Gung Memorial Hospital
Under the Management of Chang Gung Medical Foundation
Kaohsiung Medical University

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin’s effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring’s kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.

Original language	English
Article number	8105
Journal	International Journal of Molecular Sciences
Volume	24
Issue number	9
DOIs	https://doi.org/10.3390/ijms24098105
State	Published - 30 04 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

antioxidant
circadian rhythm
developmental origin of health and disease (DOHaD)
developmental programming
kidney disease
melatonin
pregnancy
Pineal Gland
Renal Insufficiency, Chronic/drug therapy
Circadian Rhythm
Kidney
Animals
Models, Animal
Melatonin/pharmacology

Access to Document

10.3390/ijms24098105

Cite this

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title = "Melatonin and Kidney Health: From Fetal Stage to Later Life",

abstract = "Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin{\textquoteright}s effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring{\textquoteright}s kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.",

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author = "Tang, \{Kuo Shu\} and Ho, \{Chun Yi\} and Hsu, \{Chien Ning\} and Tain, \{You Lin\}",

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year = "2023",

month = apr,

day = "30",

doi = "10.3390/ijms24098105",

language = "英语",

volume = "24",

journal = "International Journal of Molecular Sciences",

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TY - JOUR

T1 - Melatonin and Kidney Health

T2 - From Fetal Stage to Later Life

AU - Tang, Kuo Shu

AU - Ho, Chun Yi

AU - Hsu, Chien Ning

AU - Tain, You Lin

PY - 2023/4/30

Y1 - 2023/4/30

N2 - Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin’s effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring’s kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.

AB - Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin’s effect on kidney development, its clinical uses in the early stage of life, animal models documenting preventive applications of melatonin on offspring’s kidney-related disease, and a thorough summary of therapeutic considerations concerning melatonin supplementation.

KW - antioxidant

KW - circadian rhythm

KW - developmental origin of health and disease (DOHaD)

KW - developmental programming

KW - kidney disease

KW - melatonin

KW - pregnancy

KW - Pineal Gland

KW - Renal Insufficiency, Chronic/drug therapy

KW - Circadian Rhythm

KW - Kidney

KW - Animals

KW - Models, Animal

KW - Melatonin/pharmacology

UR - https://www.scopus.com/pages/publications/85159269814

U2 - 10.3390/ijms24098105

DO - 10.3390/ijms24098105

M3 - 文献综述

C2 - 37175813

AN - SCOPUS:85159269814

SN - 1661-6596

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 9

M1 - 8105

ER -

Melatonin and Kidney Health: From Fetal Stage to Later Life

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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