Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling

Su Chen Wang; Yi Chuan Huang; Chih Cheng Hsiao; Jiunn Ming Sheen; Li Tung Huang; Wan Shan Lo; Hsin Yi Hsieh; Yu Chieh Chen

doi:10.1002/jbt.23323

Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling

Su Chen Wang
, Yi Chuan Huang
, Chih Cheng Hsiao
, Jiunn Ming Sheen
, Li Tung Huang
, Wan Shan Lo
, Hsin Yi Hsieh
, Yu Chieh Chen^*

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

With the improvement in children's acute lymphoblastic leukemia (ALL) care, the survival rate in children ALL has improved much. Methotrexate (MTX) plays an essential role in the success of children's ALL treatment. Since hepatotoxicity is commonly reported in individuals treated with intravenous or oral MTX, our study further examined the hepatic effect following intrathecal MTX treatment, which is an essential treatment for leukemia patients. Specifically, we examined the pathogenesis of MTX hepatotoxicity in young rats and explored the impact of melatonin treatment in protection against MTX hepatotoxicity. Successfully, we found that melatonin was able to protect against MTX hepatotoxicity.

Original language	English
Article number	e23323
Pages (from-to)	e23323
Journal	Journal of Biochemical and Molecular Toxicology
Volume	37
Issue number	5
DOIs	https://doi.org/10.1002/jbt.23323
State	Published - 05 2023

Bibliographical note

Keywords

PI3K/Akt/mTOR
hepatotoxicity
melatonin
methotrexate
Rats
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Phosphatidylinositol 3-Kinases
Methotrexate/toxicity
Proto-Oncogene Proteins c-akt
Chemical and Drug Induced Liver Injury/etiology
Animals
TOR Serine-Threonine Kinases
Melatonin/pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jbt.23323

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@article{3806d11c78d74da9a30d8fa179bb90b5,

title = "Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling",

abstract = "With the improvement in children's acute lymphoblastic leukemia (ALL) care, the survival rate in children ALL has improved much. Methotrexate (MTX) plays an essential role in the success of children's ALL treatment. Since hepatotoxicity is commonly reported in individuals treated with intravenous or oral MTX, our study further examined the hepatic effect following intrathecal MTX treatment, which is an essential treatment for leukemia patients. Specifically, we examined the pathogenesis of MTX hepatotoxicity in young rats and explored the impact of melatonin treatment in protection against MTX hepatotoxicity. Successfully, we found that melatonin was able to protect against MTX hepatotoxicity.",

keywords = "PI3K/Akt/mTOR, hepatotoxicity, melatonin, methotrexate, Rats, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Phosphatidylinositol 3-Kinases, Methotrexate/toxicity, Proto-Oncogene Proteins c-akt, Chemical and Drug Induced Liver Injury/etiology, Animals, TOR Serine-Threonine Kinases, Melatonin/pharmacology",

author = "Wang, \{Su Chen\} and Huang, \{Yi Chuan\} and Hsiao, \{Chih Cheng\} and Sheen, \{Jiunn Ming\} and Huang, \{Li Tung\} and Lo, \{Wan Shan\} and Hsieh, \{Hsin Yi\} and Chen, \{Yu Chieh\}",

note = "{\textcopyright} 2023 Wiley Periodicals LLC.",

year = "2023",

month = may,

doi = "10.1002/jbt.23323",

language = "英语",

volume = "37",

pages = "e23323",

journal = "Journal of Biochemical and Molecular Toxicology",

issn = "1095-6670",

publisher = "John Wiley \& Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Melatonin protects against methotrexate hepatotoxicity in young rats

T2 - Impact of PI3K/Akt/mTOR signaling

AU - Wang, Su Chen

AU - Huang, Yi Chuan

AU - Hsiao, Chih Cheng

AU - Sheen, Jiunn Ming

AU - Huang, Li Tung

AU - Lo, Wan Shan

AU - Hsieh, Hsin Yi

AU - Chen, Yu Chieh

PY - 2023/5

Y1 - 2023/5

N2 - With the improvement in children's acute lymphoblastic leukemia (ALL) care, the survival rate in children ALL has improved much. Methotrexate (MTX) plays an essential role in the success of children's ALL treatment. Since hepatotoxicity is commonly reported in individuals treated with intravenous or oral MTX, our study further examined the hepatic effect following intrathecal MTX treatment, which is an essential treatment for leukemia patients. Specifically, we examined the pathogenesis of MTX hepatotoxicity in young rats and explored the impact of melatonin treatment in protection against MTX hepatotoxicity. Successfully, we found that melatonin was able to protect against MTX hepatotoxicity.

AB - With the improvement in children's acute lymphoblastic leukemia (ALL) care, the survival rate in children ALL has improved much. Methotrexate (MTX) plays an essential role in the success of children's ALL treatment. Since hepatotoxicity is commonly reported in individuals treated with intravenous or oral MTX, our study further examined the hepatic effect following intrathecal MTX treatment, which is an essential treatment for leukemia patients. Specifically, we examined the pathogenesis of MTX hepatotoxicity in young rats and explored the impact of melatonin treatment in protection against MTX hepatotoxicity. Successfully, we found that melatonin was able to protect against MTX hepatotoxicity.

KW - PI3K/Akt/mTOR

KW - hepatotoxicity

KW - melatonin

KW - methotrexate

KW - Rats

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Phosphatidylinositol 3-Kinases

KW - Methotrexate/toxicity

KW - Proto-Oncogene Proteins c-akt

KW - Chemical and Drug Induced Liver Injury/etiology

KW - Animals

KW - TOR Serine-Threonine Kinases

KW - Melatonin/pharmacology

UR - https://www.scopus.com/pages/publications/85150513747

U2 - 10.1002/jbt.23323

DO - 10.1002/jbt.23323

M3 - 文章

C2 - 36890697

AN - SCOPUS:85150513747

SN - 1095-6670

VL - 37

SP - e23323

JO - Journal of Biochemical and Molecular Toxicology

JF - Journal of Biochemical and Molecular Toxicology

IS - 5

M1 - e23323

ER -

Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling

Abstract

Bibliographical note

Keywords

UN SDGs

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