Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids

Cheng Yeu Wu; Jan Martel; Wei Yun Cheng; Chao Chih He; David M. Ojcius; John D. Young

doi:10.1074/jbc.M113.492157

Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids

Cheng Yeu Wu, Jan Martel, Wei Yun Cheng, Chao Chih He, David M. Ojcius, John D. Young^*

^*Corresponding author for this work

Center for Molecular and Clinical Immunology

Research output: Contribution to journal › Journal Article › peer-review

27 Scopus citations

Abstract

Background: Membrane vesicles (MVs) released from various cells are associated with human diseases. Results: MVs isolated from human serum induce the formation of mineralo-organic nanoparticles in culture. Conclusion: MVs represent a nucleating factor that promotes the formation of mineralo-organic nanoparticles and the precipitation of mineral deposits in body fluids. Significance: The ectopic precipitation of carbonate apatite deposits in body fluids and tissues may be initiated in part by MVs.

Original language	English
Pages (from-to)	30571-30584
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.492157
State	Published - 18 10 2013

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10.1074/jbc.M113.492157

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title = "Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids",

abstract = "Background: Membrane vesicles (MVs) released from various cells are associated with human diseases. Results: MVs isolated from human serum induce the formation of mineralo-organic nanoparticles in culture. Conclusion: MVs represent a nucleating factor that promotes the formation of mineralo-organic nanoparticles and the precipitation of mineral deposits in body fluids. Significance: The ectopic precipitation of carbonate apatite deposits in body fluids and tissues may be initiated in part by MVs.",

author = "Wu, {Cheng Yeu} and Jan Martel and Cheng, {Wei Yun} and He, {Chao Chih} and Ojcius, {David M.} and Young, {John D.}",

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AU - Wu, Cheng Yeu

AU - Martel, Jan

AU - Cheng, Wei Yun

AU - He, Chao Chih

AU - Ojcius, David M.

AU - Young, John D.

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: Membrane vesicles (MVs) released from various cells are associated with human diseases. Results: MVs isolated from human serum induce the formation of mineralo-organic nanoparticles in culture. Conclusion: MVs represent a nucleating factor that promotes the formation of mineralo-organic nanoparticles and the precipitation of mineral deposits in body fluids. Significance: The ectopic precipitation of carbonate apatite deposits in body fluids and tissues may be initiated in part by MVs.

AB - Background: Membrane vesicles (MVs) released from various cells are associated with human diseases. Results: MVs isolated from human serum induce the formation of mineralo-organic nanoparticles in culture. Conclusion: MVs represent a nucleating factor that promotes the formation of mineralo-organic nanoparticles and the precipitation of mineral deposits in body fluids. Significance: The ectopic precipitation of carbonate apatite deposits in body fluids and tissues may be initiated in part by MVs.

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DO - 10.1074/jbc.M113.492157

M3 - 文章

C2 - 23990473

AN - SCOPUS:84886907660

SN - 0021-9258

VL - 288

SP - 30571

EP - 30584

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 42

ER -

Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids

Abstract

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