Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids

Cheng Yeu Wu; Jan Martel; Wei Yun Cheng; Chao Chih He; David M. Ojcius; John D. Young

doi:10.1074/jbc.M113.492157

Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids

Cheng Yeu Wu
, Jan Martel
, Wei Yun Cheng
, Chao Chih He
, David M. Ojcius
, John D. Young^*

^*Corresponding author for this work

Center for Molecular and Clinical Immunology

Chang Gung University
University of California Merced
Rockefeller University
Ming Chi University of Technology

Research output: Contribution to journal › Journal Article › peer-review

27 Scopus citations

Abstract

Background: Membrane vesicles (MVs) released from various cells are associated with human diseases. Results: MVs isolated from human serum induce the formation of mineralo-organic nanoparticles in culture. Conclusion: MVs represent a nucleating factor that promotes the formation of mineralo-organic nanoparticles and the precipitation of mineral deposits in body fluids. Significance: The ectopic precipitation of carbonate apatite deposits in body fluids and tissues may be initiated in part by MVs.

Original language	English
Pages (from-to)	30571-30584
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.492157
State	Published - 18 10 2013

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10.1074/jbc.M113.492157

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title = "Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids",

abstract = "Background: Membrane vesicles (MVs) released from various cells are associated with human diseases. Results: MVs isolated from human serum induce the formation of mineralo-organic nanoparticles in culture. Conclusion: MVs represent a nucleating factor that promotes the formation of mineralo-organic nanoparticles and the precipitation of mineral deposits in body fluids. Significance: The ectopic precipitation of carbonate apatite deposits in body fluids and tissues may be initiated in part by MVs.",

author = "Wu, \{Cheng Yeu\} and Jan Martel and Cheng, \{Wei Yun\} and He, \{Chao Chih\} and Ojcius, \{David M.\} and Young, \{John D.\}",

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T1 - Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids

AU - Wu, Cheng Yeu

AU - Martel, Jan

AU - Cheng, Wei Yun

AU - He, Chao Chih

AU - Ojcius, David M.

AU - Young, John D.

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: Membrane vesicles (MVs) released from various cells are associated with human diseases. Results: MVs isolated from human serum induce the formation of mineralo-organic nanoparticles in culture. Conclusion: MVs represent a nucleating factor that promotes the formation of mineralo-organic nanoparticles and the precipitation of mineral deposits in body fluids. Significance: The ectopic precipitation of carbonate apatite deposits in body fluids and tissues may be initiated in part by MVs.

AB - Background: Membrane vesicles (MVs) released from various cells are associated with human diseases. Results: MVs isolated from human serum induce the formation of mineralo-organic nanoparticles in culture. Conclusion: MVs represent a nucleating factor that promotes the formation of mineralo-organic nanoparticles and the precipitation of mineral deposits in body fluids. Significance: The ectopic precipitation of carbonate apatite deposits in body fluids and tissues may be initiated in part by MVs.

UR - https://www.scopus.com/pages/publications/84886907660

U2 - 10.1074/jbc.M113.492157

DO - 10.1074/jbc.M113.492157

M3 - 文章

C2 - 23990473

AN - SCOPUS:84886907660

SN - 0021-9258

VL - 288

SP - 30571

EP - 30584

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 42

ER -

Membrane vesicles nucleate mineralo-organic nanoparticles and induce carbonate apatite precipitation in human body fluids

Abstract

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