Metabolic gene polymorphism frequencies in control populations

Seymour Garte; Seymour Garte; Laura Gaspari; Anna Karin Alexandrie; Agneta Rannug; Magnus Ingelman-Sundberg; Irene Persson; Christine Ambrosone; Herman Autrup; Judith L. Autrup; Helena Baranova; Lise Bathum; Paolo Boffetta; Katja Breskvar; Vita Dolzan; Jurgen Brockmoller; Ingolf Cascorbi; Margie L. Clapper; Carolyn M. Dresler; Christiane Coutelle; Ann Daly; Marco Dell’Omo; Anthony Fryer; Richard C. Strange; Aage Haugen; David Ryberg; David W. Hein; Allan Hildesheim; Ari Hirvonen; Ling Ling Hsieh; Ivan Kalina; Jan Salagovic; Daehee Kang; Masahiro Kihara; Kazumasa Noda; Chikako Kiyohara; Pierre Kremers; Liliane Roelandt; Philip Lazarus; Loéc Le Marchand; Maria Celeste Lechner; Ester M.M. Van Lieshout; Wilbert H.M. Peters; Stephanie London; Johannes J. Manni; Christine M. Maugard; Shunji Morita; Valle Nazar-Stewart; Yoshio Oda; Fritz F. Parl; Roberta Pastorelli; Timothy Rebbeck; Angela Risch; Marjorie Romkes; Bernadette Schoket; Janeric Seidegard; Peter G. Shields; Edith Sim; Daniel Sinnet; Haruhiko Sugimura; Jordi To-Figueras; Paolo Vineis; Mimi C. Yu; Emanuela Taioli

Metabolic gene polymorphism frequencies in control populations

Seymour Garte, Seymour Garte, Laura Gaspari, Anna Karin Alexandrie, Agneta Rannug, Magnus Ingelman-Sundberg, Irene Persson, Christine Ambrosone, Herman Autrup, Judith L. Autrup, Helena Baranova, Lise Bathum, Paolo Boffetta, Katja Breskvar, Vita Dolzan, Jurgen Brockmoller, Ingolf Cascorbi, Margie L. Clapper, Carolyn M. Dresler, Christiane CoutelleAnn Daly, Marco Dell’Omo, Anthony Fryer, Richard C. Strange, Aage Haugen, David Ryberg, David W. Hein, Allan Hildesheim, Ari Hirvonen, Ling Ling Hsieh, Ivan Kalina, Jan Salagovic, Daehee Kang, Masahiro Kihara, Kazumasa Noda, Chikako Kiyohara, Pierre Kremers, Liliane Roelandt, Philip Lazarus, Loéc Le Marchand, Maria Celeste Lechner, Ester M.M. Van Lieshout, Wilbert H.M. Peters, Stephanie London, Johannes J. Manni, Christine M. Maugard, Shunji Morita, Valle Nazar-Stewart, Yoshio Oda, Fritz F. Parl, Roberta Pastorelli, Timothy Rebbeck, Angela Risch, Marjorie Romkes, Bernadette Schoket, Janeric Seidegard, Peter G. Shields, Edith Sim, Daniel Sinnet, Haruhiko Sugimura, Jordi To-Figueras, Paolo Vineis, Mimi C. Yu, Emanuela Taioli

Research output: Contribution to journal › Journal Article › peer-review

815 Scopus citations

Abstract

Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15, 000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12, 525), Asians (n = 2, 136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.

Original language	English
Pages (from-to)	1239-1248
Number of pages	10
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	10
Issue number	12
State	Published - 2001
Externally published	Yes

Cite this

Garte, S., Garte, S., Gaspari, L., Alexandrie, A. K., Rannug, A., Ingelman-Sundberg, M., Persson, I., Ambrosone, C., Autrup, H., Autrup, J. L., Baranova, H., Bathum, L., Boffetta, P., Breskvar, K., Dolzan, V., Brockmoller, J., Cascorbi, I., Clapper, M. L., Dresler, C. M., ... Taioli, E. (2001). Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiology Biomarkers and Prevention, 10(12), 1239-1248.

@article{25c85c462dfc456a926a9393edb5fc19,

title = "Metabolic gene polymorphism frequencies in control populations",

abstract = "Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15, 000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12, 525), Asians (n = 2, 136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.",

author = "Seymour Garte and Seymour Garte and Laura Gaspari and Alexandrie, {Anna Karin} and Agneta Rannug and Magnus Ingelman-Sundberg and Irene Persson and Christine Ambrosone and Herman Autrup and Autrup, {Judith L.} and Helena Baranova and Lise Bathum and Paolo Boffetta and Katja Breskvar and Vita Dolzan and Jurgen Brockmoller and Ingolf Cascorbi and Clapper, {Margie L.} and Dresler, {Carolyn M.} and Christiane Coutelle and Ann Daly and Marco Dell{\textquoteright}Omo and Anthony Fryer and Strange, {Richard C.} and Aage Haugen and David Ryberg and Hein, {David W.} and Allan Hildesheim and Ari Hirvonen and Hsieh, {Ling Ling} and Ivan Kalina and Jan Salagovic and Daehee Kang and Masahiro Kihara and Kazumasa Noda and Chikako Kiyohara and Pierre Kremers and Liliane Roelandt and Philip Lazarus and {Le Marchand}, Lo{\'e}c and Lechner, {Maria Celeste} and {Van Lieshout}, {Ester M.M.} and Peters, {Wilbert H.M.} and Stephanie London and Manni, {Johannes J.} and Maugard, {Christine M.} and Shunji Morita and Valle Nazar-Stewart and Yoshio Oda and Parl, {Fritz F.} and Roberta Pastorelli and Timothy Rebbeck and Angela Risch and Marjorie Romkes and Bernadette Schoket and Janeric Seidegard and Shields, {Peter G.} and Edith Sim and Daniel Sinnet and Haruhiko Sugimura and Jordi To-Figueras and Paolo Vineis and Yu, {Mimi C.} and Emanuela Taioli",

year = "2001",

language = "英语",

volume = "10",

pages = "1239--1248",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "12",

}

Garte, S, Garte, S, Gaspari, L, Alexandrie, AK, Rannug, A, Ingelman-Sundberg, M, Persson, I, Ambrosone, C, Autrup, H, Autrup, JL, Baranova, H, Bathum, L, Boffetta, P, Breskvar, K, Dolzan, V, Brockmoller, J, Cascorbi, I, Clapper, ML, Dresler, CM, Coutelle, C, Daly, A, Dell’Omo, M, Fryer, A, Strange, RC, Haugen, A, Ryberg, D, Hein, DW, Hildesheim, A, Hirvonen, A, Hsieh, LL, Kalina, I, Salagovic, J, Kang, D, Kihara, M, Noda, K, Kiyohara, C, Kremers, P, Roelandt, L, Lazarus, P, Le Marchand, L, Lechner, MC, Van Lieshout, EMM, Peters, WHM, London, S, Manni, JJ, Maugard, CM, Morita, S, Nazar-Stewart, V, Oda, Y, Parl, FF, Pastorelli, R, Rebbeck, T, Risch, A, Romkes, M, Schoket, B, Seidegard, J, Shields, PG, Sim, E, Sinnet, D, Sugimura, H, To-Figueras, J, Vineis, P, Yu, MC & Taioli, E 2001, 'Metabolic gene polymorphism frequencies in control populations', Cancer Epidemiology Biomarkers and Prevention, vol. 10, no. 12, pp. 1239-1248.

TY - JOUR

T1 - Metabolic gene polymorphism frequencies in control populations

AU - Garte, Seymour

AU - Gaspari, Laura

AU - Alexandrie, Anna Karin

AU - Rannug, Agneta

AU - Ingelman-Sundberg, Magnus

AU - Persson, Irene

AU - Ambrosone, Christine

AU - Autrup, Herman

AU - Autrup, Judith L.

AU - Baranova, Helena

AU - Bathum, Lise

AU - Boffetta, Paolo

AU - Breskvar, Katja

AU - Dolzan, Vita

AU - Brockmoller, Jurgen

AU - Cascorbi, Ingolf

AU - Clapper, Margie L.

AU - Dresler, Carolyn M.

AU - Coutelle, Christiane

AU - Daly, Ann

AU - Dell’Omo, Marco

AU - Fryer, Anthony

AU - Strange, Richard C.

AU - Haugen, Aage

AU - Ryberg, David

AU - Hein, David W.

AU - Hildesheim, Allan

AU - Hirvonen, Ari

AU - Hsieh, Ling Ling

AU - Kalina, Ivan

AU - Salagovic, Jan

AU - Kang, Daehee

AU - Kihara, Masahiro

AU - Noda, Kazumasa

AU - Kiyohara, Chikako

AU - Kremers, Pierre

AU - Roelandt, Liliane

AU - Lazarus, Philip

AU - Le Marchand, Loéc

AU - Lechner, Maria Celeste

AU - Van Lieshout, Ester M.M.

AU - Peters, Wilbert H.M.

AU - London, Stephanie

AU - Manni, Johannes J.

AU - Maugard, Christine M.

AU - Morita, Shunji

AU - Nazar-Stewart, Valle

AU - Oda, Yoshio

AU - Parl, Fritz F.

AU - Pastorelli, Roberta

AU - Rebbeck, Timothy

AU - Risch, Angela

AU - Romkes, Marjorie

AU - Schoket, Bernadette

AU - Seidegard, Janeric

AU - Shields, Peter G.

AU - Sim, Edith

AU - Sinnet, Daniel

AU - Sugimura, Haruhiko

AU - To-Figueras, Jordi

AU - Vineis, Paolo

AU - Yu, Mimi C.

AU - Taioli, Emanuela

PY - 2001

Y1 - 2001

N2 - Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15, 000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12, 525), Asians (n = 2, 136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.

AB - Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15, 000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12, 525), Asians (n = 2, 136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.

UR - http://www.scopus.com/inward/record.url?scp=0035660166&partnerID=8YFLogxK

M3 - 文章

C2 - 11751440

AN - SCOPUS:0035660166

SN - 1055-9965

VL - 10

SP - 1239

EP - 1248

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 12

ER -

Metabolic gene polymorphism frequencies in control populations

Abstract

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