TY - JOUR
T1 - Metabolic syndrome and the risk of suicide
T2 - A community-based integrated screening samples cohort study
AU - Chang, Jung Chen
AU - Yen, Amy Ming Fang
AU - Lee, Chau Shoun
AU - Chen, Sam Li Sheng
AU - Chiu, Sherry Yueh Hsia
AU - Fann, Jean Ching Yuan
AU - Chen, Hsiu Hsi
PY - 2013
Y1 - 2013
N2 - OBJECTIVE: Metabolic syndrome (MetS) is reportedly associated with mental disorders that are known to increase the risk of suicide. However, it is not known whether this association is independent of other risk indicators of suicide. This study therefore investigated whether metabolic abnormalities increase the risk of suicide during a 10-year follow-up period. METHODS: This prospective study enrolled participants from a community-based integrated screening samples cohort in Taiwan. Of the 76,297 people recruited for this study, 12,094 had MetS at baseline. The independent variables were MetS and its components such as high blood pressure and high blood lipid levels. The outcome was death from suicide (n = 146). RESULTS: MetS was associated with an increased risk of suicide risk by 16% per MetS component (95% confidence interval [CI] = 1%-33%), adjusting for demographics, life-style factors, and clinical correlates. Of the five MetS components, elevated blood pressure was independently associated with suicide-related mortality (adjusted hazard ratio [aHR] = 1.49, 95% CI = 1.03-2.15). CONCLUSIONS: This analysis of community-based longitudinal data showed that MetS and its components, particularly elevated blood pressure, correlated positively with suicide risk after controlling other factors. Therefore, public mental health interventions targeting suicide reduction may need to specifically focus on individuals with hypertension and other components of the MetS.
AB - OBJECTIVE: Metabolic syndrome (MetS) is reportedly associated with mental disorders that are known to increase the risk of suicide. However, it is not known whether this association is independent of other risk indicators of suicide. This study therefore investigated whether metabolic abnormalities increase the risk of suicide during a 10-year follow-up period. METHODS: This prospective study enrolled participants from a community-based integrated screening samples cohort in Taiwan. Of the 76,297 people recruited for this study, 12,094 had MetS at baseline. The independent variables were MetS and its components such as high blood pressure and high blood lipid levels. The outcome was death from suicide (n = 146). RESULTS: MetS was associated with an increased risk of suicide risk by 16% per MetS component (95% confidence interval [CI] = 1%-33%), adjusting for demographics, life-style factors, and clinical correlates. Of the five MetS components, elevated blood pressure was independently associated with suicide-related mortality (adjusted hazard ratio [aHR] = 1.49, 95% CI = 1.03-2.15). CONCLUSIONS: This analysis of community-based longitudinal data showed that MetS and its components, particularly elevated blood pressure, correlated positively with suicide risk after controlling other factors. Therefore, public mental health interventions targeting suicide reduction may need to specifically focus on individuals with hypertension and other components of the MetS.
KW - blood pressure
KW - community-based integrated screening samples
KW - hypertension
KW - metabolic syndrome
KW - mood disorders
KW - suicide
UR - http://www.scopus.com/inward/record.url?scp=84888127431&partnerID=8YFLogxK
U2 - 10.1097/PSY.0000000000000014
DO - 10.1097/PSY.0000000000000014
M3 - 文章
C2 - 24163389
AN - SCOPUS:84888127431
SN - 0033-3174
VL - 75
SP - 807
EP - 814
JO - Psychosomatic Medicine
JF - Psychosomatic Medicine
IS - 9
ER -
