Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress

You Lin Tain, Chien Ning Hsu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Metabolic syndrome (MetS) is a worldwide public health issue characterized by a set of risk factors for cardiovascular disease. MetS can originate in early life by developmental programming. Increasing evidence suggests that oxidative stress, which is characterized as an imbalance between reactive oxygen species (ROS), nitric oxide (NO), and antioxidant systems, plays a decisive role in MetS programming. Results from human and animal studies indicate that maternal-derived insults induce MetS later in life, accompanied by oxidative stress programming of various organ systems. On the contrary, perinatal use of antioxidants can offset oxidative stress and thereby prevent MetS traits in adult offspring. This review provides an overview of current knowledge about the core mechanisms behind MetS programming, with particular focus on the occurrence of oxidative-stress-related pathogenesis as well as the use of potential oxidative-stress-targeted interventions as a reprogramming strategy to avert MetS of developmental origins. Future clinical studies should provide important proof of concept for the effectiveness of these reprogramming interventions to prevent a MetS epidemic.

Original languageEnglish
Article number2108
JournalAntioxidants
Volume11
Issue number11
DOIs
StatePublished - 11 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

Keywords

  • antioxidant
  • developmental origins of health and disease (DOHaD)
  • hypertension
  • metabolic syndrome
  • nitric oxide
  • obesity
  • oxidative stress
  • reactive oxygen species

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