TY - JOUR
T1 - Metabolic tumor volume by 18 F-FDG PET/CT is prognostic for stage IVB endometrial carcinoma
AU - Liu, Feng Yuan
AU - Chao, Angel
AU - Lai, Chyong Huey
AU - Chou, Hung Hsueh
AU - Yen, Tzu Chen
PY - 2012/6
Y1 - 2012/6
N2 - Objective: The objective of this study was to evaluate the potential prognostic factors in patients with primary stage IVB endometrial carcinoma, incorporating parameters from 18 F-FDG PET/CT such as standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Methods: Patients with primary M1 endometrial carcinoma who received 18 F-FDG PET/CT before treatment were retrospectively analyzed. Histological type, histological grade, T stage, N stage, age, ECOG performance status, hormone receptor status, metastatic patterns, number of involved metastatic patterns, serum CA125 level, and 18 F-FDG PET/CT derived parameters including total body SUVmax, total body MTV, and total body TLG were considered as potential prognostic factors for overall survival. Cox proportional hazards regression model was used for statistical analysis. Results: Fifteen patients were eligible with a median survival of 17 months. Total body MTV and total body TLG were highly collinear (Pearson's r = 0.978) and were found to be significant prognosticators (P = 0.010 and 0.011 respectively). Four patients with total body MTV above 450 mL (or total body TLG above 2700 g) had a median survival of two months, while the remaining patients had a median survival of 47 months. Conclusion: Total body MTV is a significant prognostic factor for overall survival in patients with stage IVB endometrial carcinoma. Patients with total body MTV above 450 mL had a very poor survival, while more aggressive therapy may be considered in the remaining patients in pursuit of prolonged survival.
AB - Objective: The objective of this study was to evaluate the potential prognostic factors in patients with primary stage IVB endometrial carcinoma, incorporating parameters from 18 F-FDG PET/CT such as standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Methods: Patients with primary M1 endometrial carcinoma who received 18 F-FDG PET/CT before treatment were retrospectively analyzed. Histological type, histological grade, T stage, N stage, age, ECOG performance status, hormone receptor status, metastatic patterns, number of involved metastatic patterns, serum CA125 level, and 18 F-FDG PET/CT derived parameters including total body SUVmax, total body MTV, and total body TLG were considered as potential prognostic factors for overall survival. Cox proportional hazards regression model was used for statistical analysis. Results: Fifteen patients were eligible with a median survival of 17 months. Total body MTV and total body TLG were highly collinear (Pearson's r = 0.978) and were found to be significant prognosticators (P = 0.010 and 0.011 respectively). Four patients with total body MTV above 450 mL (or total body TLG above 2700 g) had a median survival of two months, while the remaining patients had a median survival of 47 months. Conclusion: Total body MTV is a significant prognostic factor for overall survival in patients with stage IVB endometrial carcinoma. Patients with total body MTV above 450 mL had a very poor survival, while more aggressive therapy may be considered in the remaining patients in pursuit of prolonged survival.
KW - Distant metastasis
KW - Endometrial carcinoma
KW - F-FDG PET/CT
KW - Metabolic tumor volume
KW - Prognosis
KW - Total lesion glycolysis
UR - http://www.scopus.com/inward/record.url?scp=84861189072&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2012.03.021
DO - 10.1016/j.ygyno.2012.03.021
M3 - 文章
C2 - 22440787
AN - SCOPUS:84861189072
SN - 0090-8258
VL - 125
SP - 566
EP - 571
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 3
ER -