MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma

Wei Chen Yen; Kai Ping Chang; Cheng Yi Chen; Yenlin Huang; Ting Wen Chen; Hsing Wen Cheng; Jui Shan Yi; Chun Chia Cheng; Chih Ching Wu; Chun I. Wang

doi:10.1186/s12935-023-02956-0

MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma

Wei Chen Yen, Kai Ping Chang, Cheng Yi Chen, Yenlin Huang, Ting Wen Chen, Hsing Wen Cheng, Jui Shan Yi, Chun Chia Cheng, Chih Ching Wu, Chun I. Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

Abstract

Oral squamous cell carcinoma (OSCC) is the predominant histological type of the head and neck squamous cell carcinoma (HNSCC). By comparing the differentially expressed genes (DEGs) in OSCC-TCGA patients with copy number variations (CNVs) that we identify in OSCC-OncoScan dataset, we herein identified 37 dysregulated candidate genes. Among these potential candidate genes, 26 have been previously reported as dysregulated proteins or genes in HNSCC. Among 11 novel candidates, the overall survival analysis revealed that melanotransferrin (MFI2) is the most significant prognostic molecular in OSCC-TCGA patients. Another independent Taiwanese cohort confirmed that higher MFI2 transcript levels were significantly associated with poor prognosis. Mechanistically, we found that knockdown of MFI2 reduced cell viability, migration and invasion via modulating EGF/FAK signaling in OSCC cells. Collectively, our results support a mechanistic understanding of a novel role for MFI2 in promoting cell invasiveness in OSCC.

Original language	English
Article number	112
Pages (from-to)	112
Journal	Cancer Cell International
Volume	23
Issue number	1
DOIs	https://doi.org/10.1186/s12935-023-02956-0
State	Published - 12 06 2023

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title = "MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma",

abstract = "Oral squamous cell carcinoma (OSCC) is the predominant histological type of the head and neck squamous cell carcinoma (HNSCC). By comparing the differentially expressed genes (DEGs) in OSCC-TCGA patients with copy number variations (CNVs) that we identify in OSCC-OncoScan dataset, we herein identified 37 dysregulated candidate genes. Among these potential candidate genes, 26 have been previously reported as dysregulated proteins or genes in HNSCC. Among 11 novel candidates, the overall survival analysis revealed that melanotransferrin (MFI2) is the most significant prognostic molecular in OSCC-TCGA patients. Another independent Taiwanese cohort confirmed that higher MFI2 transcript levels were significantly associated with poor prognosis. Mechanistically, we found that knockdown of MFI2 reduced cell viability, migration and invasion via modulating EGF/FAK signaling in OSCC cells. Collectively, our results support a mechanistic understanding of a novel role for MFI2 in promoting cell invasiveness in OSCC.",

author = "Yen, {Wei Chen} and Chang, {Kai Ping} and Chen, {Cheng Yi} and Yenlin Huang and Chen, {Ting Wen} and Cheng, {Hsing Wen} and Yi, {Jui Shan} and Cheng, {Chun Chia} and Wu, {Chih Ching} and Wang, {Chun I.}",

note = "{\textcopyright} 2023. The Author(s).",

year = "2023",

month = jun,

day = "12",

doi = "10.1186/s12935-023-02956-0",

language = "英语",

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TY - JOUR

T1 - MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma

AU - Yen, Wei Chen

AU - Chang, Kai Ping

AU - Chen, Cheng Yi

AU - Huang, Yenlin

AU - Chen, Ting Wen

AU - Cheng, Hsing Wen

AU - Yi, Jui Shan

AU - Cheng, Chun Chia

AU - Wu, Chih Ching

AU - Wang, Chun I.

PY - 2023/6/12

Y1 - 2023/6/12

N2 - Oral squamous cell carcinoma (OSCC) is the predominant histological type of the head and neck squamous cell carcinoma (HNSCC). By comparing the differentially expressed genes (DEGs) in OSCC-TCGA patients with copy number variations (CNVs) that we identify in OSCC-OncoScan dataset, we herein identified 37 dysregulated candidate genes. Among these potential candidate genes, 26 have been previously reported as dysregulated proteins or genes in HNSCC. Among 11 novel candidates, the overall survival analysis revealed that melanotransferrin (MFI2) is the most significant prognostic molecular in OSCC-TCGA patients. Another independent Taiwanese cohort confirmed that higher MFI2 transcript levels were significantly associated with poor prognosis. Mechanistically, we found that knockdown of MFI2 reduced cell viability, migration and invasion via modulating EGF/FAK signaling in OSCC cells. Collectively, our results support a mechanistic understanding of a novel role for MFI2 in promoting cell invasiveness in OSCC.

AB - Oral squamous cell carcinoma (OSCC) is the predominant histological type of the head and neck squamous cell carcinoma (HNSCC). By comparing the differentially expressed genes (DEGs) in OSCC-TCGA patients with copy number variations (CNVs) that we identify in OSCC-OncoScan dataset, we herein identified 37 dysregulated candidate genes. Among these potential candidate genes, 26 have been previously reported as dysregulated proteins or genes in HNSCC. Among 11 novel candidates, the overall survival analysis revealed that melanotransferrin (MFI2) is the most significant prognostic molecular in OSCC-TCGA patients. Another independent Taiwanese cohort confirmed that higher MFI2 transcript levels were significantly associated with poor prognosis. Mechanistically, we found that knockdown of MFI2 reduced cell viability, migration and invasion via modulating EGF/FAK signaling in OSCC cells. Collectively, our results support a mechanistic understanding of a novel role for MFI2 in promoting cell invasiveness in OSCC.

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DO - 10.1186/s12935-023-02956-0

M3 - 文章

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AN - SCOPUS:85161828466

SN - 1475-2867

VL - 23

SP - 112

JO - Cancer Cell International

JF - Cancer Cell International

IS - 1

M1 - 112

ER -

MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma

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