Microbial Analysis in Chronic Rhinosinusitis Patients with Chronic Kidney Disease and End-Stage Renal Disease

Sheng Wei Lo, Meng Chang Ding, Yao Te Tsai, Ming Shao Tsai, Chia Yen Liu, Cheng Ming Hsu, Yao Hsu Yang, Geng He Chang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

Abstract

Introduction: This study aimed to elucidate the bacterial profile of chronic rhinosinusitis (CRS) in patients with end-stage renal disease (ESRD) and chronic kidney disease (CKD) compared with nonrenal patients, guiding antibiotic selection for clinicians. Methods: We retrospectively analyzed 13,906 inpatients from the Chang Gung Research Database who underwent sinus surgery (2004–2018). Patients were categorized into ESRD-CRS, CKD-CRS, and non-CKD-CRS based on the estimated glomerular filtration rate. Bacterial cultures from surgical samples were classified as facultative anaerobes or aerobes (e.g., Klebsiella pneumoniae [KP], Pseudomonas aeruginosa [Ps.a]), anaerobes, and fungi and ranked by prevalence. Results: Data from 47 ESRD-CRS, 230 CKD-CRS, and 13,123 non-CKD-CRS patients were analyzed. In ESRD-CRS, the predominant species were KP (31.6%), Ps.a (21.1%), and Coagulase-negative Staphylococcus (CoNS, 15.8%). CKD-CRS showed Staphylococcus epidermidis (27.7%), CoNS (20.5%), and Ps.a (20.5%). Non-CKD-CRS had Staphylococcus epidermidis (29.8%), CoNS (25.0%), and Staphylococcus aureus (15.5%). For anaerobes, ESRD-CRS was dominated by Fusobacterium nucleatum (10.5%) and Peptostreptococcus micros (10.5%), whereas CKD-CRS and non-CKD-CRS showed Propionibacterium acnes as a primary strain (14.5% and 28.7%, respectively). Conclusion: For CRS in ESRD, antibiotics targeting KP and Fusobacterium nucleatum are recommended. In CKD-CRS, a focus on Staphylococcus epidermidis and Propionibacterium acnes is suggested. Level of Evidence: 4 Laryngoscope, 134:3499–3507, 2024.

Original languageEnglish
Pages (from-to)3499-3507
Number of pages9
JournalLaryngoscope
Volume134
Issue number8
DOIs
StateAccepted/In press - 2024

Bibliographical note

Publisher Copyright:
© 2024 The American Laryngological, Rhinological and Otological Society, Inc.

Keywords

  • Chang Gung Research Database
  • chronic kidney disease
  • end-stage renal disease
  • pathogen
  • sinusitis

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