Microbiologic and clinical implications of bacteremia due to extended-spectrum-β-lactamase-producing Klebsiella pneumoniae with or without plasmid-mediated AmpC β-lactamase DHA-1

Chen Hsiang Lee; Lin Hui Su; Chia Chin Li; Chun Chih Chien; Ya Fen Tang; Jien Wei Liu

doi:10.1128/AAC.00083-10

Microbiologic and clinical implications of bacteremia due to extended-spectrum-β-lactamase-producing Klebsiella pneumoniae with or without plasmid-mediated AmpC β-lactamase DHA-1

Chen Hsiang Lee
, Lin Hui Su
, Chia Chin Li
, Chun Chih Chien
, Ya Fen Tang
, Jien Wei Liu^*

^*Corresponding author for this work

Department of Medical Biotechnology and Laboratory Science

Research output: Contribution to journal › Journal Article › peer-review

24 Scopus citations

Abstract

Bacteremias caused by Klebsiella pneumoniae producing extended-spectrum beta-lactamase (ESBL-KP; n = 52) and producing both ESBL and AmpC-type DHA-1 beta-lactamase (ESBL-PMABL-KP; n = 20) were analyzed. Higher MIC₅₀s and MIC₉₀s for carbapenems, ciprofloxacin, and piperacillin- tazobactam were observed with ESBL-PMABL-KP than with ESBL-KP. Patients with oxyimino-β-lactam exposure and high modified Pitt bacteremia scores (HMPBSs) were at higher risk, while those with piperacillin-tazobactam and aminoglycoside exposure were at lower risk for ESBL-KP bacteremia. Patients with fluoroquinolone exposure, diabetes mellitus, and HMPBS were at higher risk, while those with aminoglycoside exposure were at lower risk, for ESBL-PMABL-KP bacteremia.

Original language	English
Pages (from-to)	5395-5398
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	54
Issue number	12
DOIs	https://doi.org/10.1128/AAC.00083-10
State	Published - 12 2010

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@article{2a790fdc58b04f378e37660a4f5ddb08,

title = "Microbiologic and clinical implications of bacteremia due to extended-spectrum-β-lactamase-producing Klebsiella pneumoniae with or without plasmid-mediated AmpC β-lactamase DHA-1",

abstract = "Bacteremias caused by Klebsiella pneumoniae producing extended-spectrum beta-lactamase (ESBL-KP; n = 52) and producing both ESBL and AmpC-type DHA-1 beta-lactamase (ESBL-PMABL-KP; n = 20) were analyzed. Higher MIC50s and MIC90s for carbapenems, ciprofloxacin, and piperacillin- tazobactam were observed with ESBL-PMABL-KP than with ESBL-KP. Patients with oxyimino-β-lactam exposure and high modified Pitt bacteremia scores (HMPBSs) were at higher risk, while those with piperacillin-tazobactam and aminoglycoside exposure were at lower risk for ESBL-KP bacteremia. Patients with fluoroquinolone exposure, diabetes mellitus, and HMPBS were at higher risk, while those with aminoglycoside exposure were at lower risk, for ESBL-PMABL-KP bacteremia.",

author = "Lee, \{Chen Hsiang\} and Su, \{Lin Hui\} and Li, \{Chia Chin\} and Chien, \{Chun Chih\} and Tang, \{Ya Fen\} and Liu, \{Jien Wei\}",

year = "2010",

month = dec,

doi = "10.1128/AAC.00083-10",

language = "英语",

volume = "54",

pages = "5395--5398",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "12",

}

Microbiologic and clinical implications of bacteremia due to extended-spectrum-β-lactamase-producing Klebsiella pneumoniae with or without plasmid-mediated AmpC β-lactamase DHA-1. / Lee, Chen Hsiang; Su, Lin Hui; Li, Chia Chin et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 12, 12.2010, p. 5395-5398.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Microbiologic and clinical implications of bacteremia due to extended-spectrum-β-lactamase-producing Klebsiella pneumoniae with or without plasmid-mediated AmpC β-lactamase DHA-1

AU - Lee, Chen Hsiang

AU - Su, Lin Hui

AU - Li, Chia Chin

AU - Chien, Chun Chih

AU - Tang, Ya Fen

AU - Liu, Jien Wei

PY - 2010/12

Y1 - 2010/12

N2 - Bacteremias caused by Klebsiella pneumoniae producing extended-spectrum beta-lactamase (ESBL-KP; n = 52) and producing both ESBL and AmpC-type DHA-1 beta-lactamase (ESBL-PMABL-KP; n = 20) were analyzed. Higher MIC50s and MIC90s for carbapenems, ciprofloxacin, and piperacillin- tazobactam were observed with ESBL-PMABL-KP than with ESBL-KP. Patients with oxyimino-β-lactam exposure and high modified Pitt bacteremia scores (HMPBSs) were at higher risk, while those with piperacillin-tazobactam and aminoglycoside exposure were at lower risk for ESBL-KP bacteremia. Patients with fluoroquinolone exposure, diabetes mellitus, and HMPBS were at higher risk, while those with aminoglycoside exposure were at lower risk, for ESBL-PMABL-KP bacteremia.

AB - Bacteremias caused by Klebsiella pneumoniae producing extended-spectrum beta-lactamase (ESBL-KP; n = 52) and producing both ESBL and AmpC-type DHA-1 beta-lactamase (ESBL-PMABL-KP; n = 20) were analyzed. Higher MIC50s and MIC90s for carbapenems, ciprofloxacin, and piperacillin- tazobactam were observed with ESBL-PMABL-KP than with ESBL-KP. Patients with oxyimino-β-lactam exposure and high modified Pitt bacteremia scores (HMPBSs) were at higher risk, while those with piperacillin-tazobactam and aminoglycoside exposure were at lower risk for ESBL-KP bacteremia. Patients with fluoroquinolone exposure, diabetes mellitus, and HMPBS were at higher risk, while those with aminoglycoside exposure were at lower risk, for ESBL-PMABL-KP bacteremia.

UR - https://www.scopus.com/pages/publications/78649661345

U2 - 10.1128/AAC.00083-10

DO - 10.1128/AAC.00083-10

M3 - 文章

C2 - 20855742

AN - SCOPUS:78649661345

SN - 0066-4804

VL - 54

SP - 5395

EP - 5398

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 12

ER -

Microbiologic and clinical implications of bacteremia due to extended-spectrum-β-lactamase-producing Klebsiella pneumoniae with or without plasmid-mediated AmpC β-lactamase DHA-1

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