Microdosimetry study of THOR BNCT beam using tissue equivalent proportional counter

F. Y. Hsu; H. W. Hsiao; C. J. Tung; H. M. Liu; F. I. Chou

doi:10.1016/j.apradiso.2009.03.043

Microdosimetry study of THOR BNCT beam using tissue equivalent proportional counter

F. Y. Hsu, H. W. Hsiao, C. J. Tung^*, H. M. Liu, F. I. Chou

^*Corresponding author for this work

Department of Medical Imaging and Radiological Sciences

National Tsing Hua University

Research output: Contribution to journal › Journal Article › peer-review

12 Scopus citations

Abstract

Boron neutron capture therapy (BNCT) is a cancer treatment modality using a nuclear reactor and a boron compound drug. In Taiwan, Tsing Hua open-pool reactor (THOR) has been modulated for the basic research of BNCT for years. A new BNCT beam port was built in 2004 and used to prepare the first clinical trial in the near future. This work reports the microdosimetry study of the THOR BNCT beam by means of the tissue equivalent proportional counter (TEPC). Two self-fabricated TEPCs (the boron-doped versus the boron-free counter wall) were introduced. These dual TEPCs were applied to measure the lineal energy distributions in air and water phantom irradiated by the THOR BNCT mixed radiation field. Dose contributions from component radiations of different linear energy transfers (LETs) were analyzed. Applying a lineal energy dependent biological weighting function, r(y), to the total and individual lineal energy distributions, the effective relative biological effectiveness (RBE), neutron RBE, photon RBE, and boron capture RBE (BNC RBE) were all determined at various depths of the water phantom. Minimum and maximum values of the effective RBE were 1.68 and 2.93, respectively. The maximum effective RBE occurred at 2 cm depth in the phantom. The average neutron RBE, photon RBE, and BNC RBE values were 3.160±0.020, 1.018±0.001, and 1.570±0.270, respectively, for the THOR BNCT beam.

Original language	English
Pages (from-to)	S175-S178
Journal	Applied Radiation and Isotopes
Volume	67
Issue number	7-8 SUPPL.
DOIs	https://doi.org/10.1016/j.apradiso.2009.03.043
State	Published - 07 2009

Keywords

BNCT
Microdosimetry
RBE
TEPC
THOR

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.apradiso.2009.03.043

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title = "Microdosimetry study of THOR BNCT beam using tissue equivalent proportional counter",

abstract = "Boron neutron capture therapy (BNCT) is a cancer treatment modality using a nuclear reactor and a boron compound drug. In Taiwan, Tsing Hua open-pool reactor (THOR) has been modulated for the basic research of BNCT for years. A new BNCT beam port was built in 2004 and used to prepare the first clinical trial in the near future. This work reports the microdosimetry study of the THOR BNCT beam by means of the tissue equivalent proportional counter (TEPC). Two self-fabricated TEPCs (the boron-doped versus the boron-free counter wall) were introduced. These dual TEPCs were applied to measure the lineal energy distributions in air and water phantom irradiated by the THOR BNCT mixed radiation field. Dose contributions from component radiations of different linear energy transfers (LETs) were analyzed. Applying a lineal energy dependent biological weighting function, r(y), to the total and individual lineal energy distributions, the effective relative biological effectiveness (RBE), neutron RBE, photon RBE, and boron capture RBE (BNC RBE) were all determined at various depths of the water phantom. Minimum and maximum values of the effective RBE were 1.68 and 2.93, respectively. The maximum effective RBE occurred at 2 cm depth in the phantom. The average neutron RBE, photon RBE, and BNC RBE values were 3.160±0.020, 1.018±0.001, and 1.570±0.270, respectively, for the THOR BNCT beam.",

keywords = "BNCT, Microdosimetry, RBE, TEPC, THOR",

author = "Hsu, {F. Y.} and Hsiao, {H. W.} and Tung, {C. J.} and Liu, {H. M.} and Chou, {F. I.}",

year = "2009",

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doi = "10.1016/j.apradiso.2009.03.043",

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pages = "S175--S178",

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TY - JOUR

T1 - Microdosimetry study of THOR BNCT beam using tissue equivalent proportional counter

AU - Hsu, F. Y.

AU - Hsiao, H. W.

AU - Tung, C. J.

AU - Liu, H. M.

AU - Chou, F. I.

PY - 2009/7

Y1 - 2009/7

N2 - Boron neutron capture therapy (BNCT) is a cancer treatment modality using a nuclear reactor and a boron compound drug. In Taiwan, Tsing Hua open-pool reactor (THOR) has been modulated for the basic research of BNCT for years. A new BNCT beam port was built in 2004 and used to prepare the first clinical trial in the near future. This work reports the microdosimetry study of the THOR BNCT beam by means of the tissue equivalent proportional counter (TEPC). Two self-fabricated TEPCs (the boron-doped versus the boron-free counter wall) were introduced. These dual TEPCs were applied to measure the lineal energy distributions in air and water phantom irradiated by the THOR BNCT mixed radiation field. Dose contributions from component radiations of different linear energy transfers (LETs) were analyzed. Applying a lineal energy dependent biological weighting function, r(y), to the total and individual lineal energy distributions, the effective relative biological effectiveness (RBE), neutron RBE, photon RBE, and boron capture RBE (BNC RBE) were all determined at various depths of the water phantom. Minimum and maximum values of the effective RBE were 1.68 and 2.93, respectively. The maximum effective RBE occurred at 2 cm depth in the phantom. The average neutron RBE, photon RBE, and BNC RBE values were 3.160±0.020, 1.018±0.001, and 1.570±0.270, respectively, for the THOR BNCT beam.

AB - Boron neutron capture therapy (BNCT) is a cancer treatment modality using a nuclear reactor and a boron compound drug. In Taiwan, Tsing Hua open-pool reactor (THOR) has been modulated for the basic research of BNCT for years. A new BNCT beam port was built in 2004 and used to prepare the first clinical trial in the near future. This work reports the microdosimetry study of the THOR BNCT beam by means of the tissue equivalent proportional counter (TEPC). Two self-fabricated TEPCs (the boron-doped versus the boron-free counter wall) were introduced. These dual TEPCs were applied to measure the lineal energy distributions in air and water phantom irradiated by the THOR BNCT mixed radiation field. Dose contributions from component radiations of different linear energy transfers (LETs) were analyzed. Applying a lineal energy dependent biological weighting function, r(y), to the total and individual lineal energy distributions, the effective relative biological effectiveness (RBE), neutron RBE, photon RBE, and boron capture RBE (BNC RBE) were all determined at various depths of the water phantom. Minimum and maximum values of the effective RBE were 1.68 and 2.93, respectively. The maximum effective RBE occurred at 2 cm depth in the phantom. The average neutron RBE, photon RBE, and BNC RBE values were 3.160±0.020, 1.018±0.001, and 1.570±0.270, respectively, for the THOR BNCT beam.

KW - BNCT

KW - Microdosimetry

KW - RBE

KW - TEPC

KW - THOR

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M3 - 文章

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AN - SCOPUS:67649406002

SN - 0969-8043

VL - 67

SP - S175-S178

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 7-8 SUPPL.

ER -

Microdosimetry study of THOR BNCT beam using tissue equivalent proportional counter

Abstract

Keywords

UN SDGs

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