MicroRNA-122 as a predictor of HBsAg seroclearance in hepatitis B and C dual infected patients treated with interferon and ribavirin

Yi Hao Yen, Chao Min Huang, Kuo Liang Wei, Jing Houng Wang, Sheng Nan Lu, Chuan Mo Lee, Chao Hung Hung, Chien Hung Chen, Po Lin Tseng, Kuo Chin Chang, Ming Chao Tsai, Ming Tsung Lin, Cheng Kun Wu, Cheng Hong Yang, Sin Hua Moi, Chung Lung Cho, Tsung Hui Hu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

8 Scopus citations

Abstract

It has been demonstrated that microRNA-122 (miR-122) plays key roles in the modulation of hepatitis B virus (HBV) replication. This study examined the role of miR-122 in patients with hepatitis C virus (HCV)-HBV dual infection with active hepatitis C who received pegylated interferon-α and ribavirin dual therapy. We enrolled 121 patients with HCV-HBV dual infection after dual therapy. Stored serum was collected before treatment. RT-PCR was used to analyze miR-122. HBsAg seroclearance was noted in 37 (30.1%) cases during a median follow-up period of 5.4 years. miR-122 was significantly lower in HBsAg seroclearance patients than in non-HBsAg seroclearance patients (P < 0.014). Multivariate analysis showed that miR-122 was an independent factor of HBsAg seroclearance (OR: 0.30, 95% CI: 0.09-0.98, P = 0.046). miR-122 was significantly higher in patients who were qHBsAg > 100 IU/mL versus ≤100 IU/mL (P < 0.001). We concluded that in patients with HBV-HCV dual infection with active hepatitis C, miR-122 was associated with HBsAg seroclearance after therapy and qHBsAg level before therapy, indicating that miR-122 plays key roles in modulating HBV replication.

Original languageEnglish
Article number33816
JournalScientific Reports
Volume6
DOIs
StatePublished - 26 09 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 The Author(s).

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